|“||Each of you has a job to do. Your debts will be repaid when were done. Go!||„|
|~ Doctor Octopus to the group.|
The Sinister Six is a team of supervillains in Marvel's Spider-Man, the PlayStation 4 videogame, drawn from the Web-Slinger's list of common enemies, who band together to defeat the Webhead (Spider-Man) and bring down Norman Osborn. Led by Doctor Octopus, the group consists of Mister Negative, Electro, Vulture, Rhino, and Scorpion.
After Mayor Osborn claims credit for the capture of Mister Negative, this infuriates Otto Octavius and pushes him over the edge. Norman had already removed funding from his projects at this point and, according to Otto, stolen his ideas and technology. Past history showed that, while they had worked together as scientists and co-founded Oscorp, Norman was quick to break the rules, such as when he used an untested substance on a young Martin Li and inadvertently created Mister Negative.
Otto assumes the mantle of Doctor Octopus to exact his revenge, breaking criminals out of Ryker's Prison and The Raft. He had researched all of the most violent, offering each of them something unique if they were to help him. Thus, they form the Sinister Six, with the singular goal of destroying Norman Osborn and Oscorp.
Meanwhile, Vulture teams up with Electro and together they set up a trap for Spider-Man, although he manages to defeat them. He then has an encounter with Scorpion, who poisons him. After having to fight against the hallucinations of his own mind and barely escaping, Spider-Man has a second encounter with Scorpion, who is now accompanied by Rhino. He ultimately defeats the duo, leaving only Mister Negative and Doctor Octopus left.
- Unlike most modern depictions of the Sinister Six, this version of the Sinister Six doesn't include Sandman or Mysterio, being replaced by Mister Negative and Scorpion.
- Unlike Mister Negative, however, Scorpion has appeared as a member of the Sinister Six in other Marvel media.
- On the other hand, Mysterio has been confirmed to exist in the universe of Marvel's Spider-Man, as during the Halloween mission it appears a woman disguised as him.