|“||Let's just say the reaper can swing his sickle at me, but I'm beyond Death's stroke now"||„|
|~ Slade to Clark Kent, "Icarus"|
Slade Wilson appears as a villain in the Tenth and final season of Smallville. He is a Member of the U.S.A army.
When Vigilante Registration act excepted and Rick Flag's Suicide Squad started to act against it Slade Wilson one of the people support the VRA, begins to push more stringent measures to control and even murder super powered heroes of the United States.
Thinking they are like the Dictators awaiting and he even start to build bases to imprison and use the heroes abilities, forcing them to work for them and for the Government.
He mainly desires Mera and Aquaman after they destroyed one of his bases. To learn what Wilson knew Oliver getting registered, Lois Lane meanwhile confronts Slade and learn Slade is a suspected war criminal known for torture and illegal methods of torture and interrogation but its too late to warn Oliver and A.C.
Slade captures both of them and start his brutal methods of interrogation. Clark and Mera free both of them but Slade started a self destruction protocol of the base they all in. Clark confronts Slade who locks him inside a Kryptonite Cage. When Clark pleads with Slade to let him save the other man, Slade refuses, wanting instead die while killing Clark.
Somehow both Clark and Slade survive the explosion but Slade appears to be in a hospital and lost his right eye. Slade is later saved from death by Darkseid with advanced military technology, losing his right eye but gaining healing abilities in the process. An Omega symbol can be seen in Slade's skull thus proven that he has been corrupted by the Darkness.
Slade later made a statement on the news framing Oliver Queen for the explosion of the Government holding cells turning the all world against the league. He arranges for the Leagues key supporters Emil Hamilton, Lois Lane, Tess Mercer to captured and held at the daily planet for interrogation on the League's whereabouts, all three of them escape the custody with the help of Clark and Cat Grant.
Later Slade finds Lois sneaking in to Oliver's office at Luthorcorp and held her hostage with a gun. Lois says they can talk it out and Slade decides not to shoot her, but she smashes a glass on his head. He grabs her and throws her against a table, temporarily knocking her out. She fought back yet Slade overpowered her.
As he was about to kill her Hawkman arrives fight Wilson. While they fight Slade stabs Hawkman in the back but a explosion occurs and thrown Slade to his defeat, İmpact causes Lois fall of the building.
Slade survives the explosion with minimal damage and he was about to get away but confronted by Clark, he sends Slade to the Phantom Zone. Clark tells Tess after the darkness gone and everything returns to normal he will bring Slade back from the Zone and put on trial.
When Slade send back to Earth from Phantom Zone by Zod, he was found in a street corner unconscious.
Slade currently lies in a coma in a military base.
After the defeat of Darkseid and arrival of Marionette Ventures Slade was still in a comatose state, doctors discovered he has a brain disease which non of them ever seen before, its like not of this Earth and they do not know when Slade is going to wake up.
It was later revealed that Slade had a daughter named Rose having the same vendetta as her father against superheroes and blaming them for his current state, decided to take down one by one any vigilante that come in her way.