The Spice Boys trapped Mr. Popo as he attempted to escape during Garlic Jr.'s invasion of Kami's Lookout, and Garlic Jr. trapped him in a bottle. He did the same to Kami. Spice asked Piccolo to join them, and have those infected by the Black Water Mist worship him, but he declined. After Piccolo was bitten, and seemingly infected by the mist, Spice held him back at the Lookout while Gohan and Krillin fought Salt and Mustard. After Gohan killed Salt and Mustard, Spice and Vinegar tried to enter the battle, but Piccolo fought Gohan instead.
After Piccolo revealed that he was pretending to be under the Black Water Mist's control, he fought Garlic Jr., and Spice fought Gohan, eventually wrapping his hair around him. However Gohan broke free and attacked Vinegar. Krillin hit Spice with his head and Gohan knocked him into a spike, seemingly killing him.
However, the Makyo Star drew ever closer to Earth, and it powered up Spice and Vinegar, healing them and enabling them to transform into bigger versions of themselves. From here, Spice beat up Gohan, and after knocking Krillin over the edge of the lookout, Vinegar fought Gohan alongside Spice. Gohan got angry at them for nearly killing Krillin, and unleashed his hidden power, destroying both Spice and Vinegar with two energy waves.
Galactic Frieza Army