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The Stuff is the titular main antagonist of the 1985 satirical sci-fi horror film of the same name. It is similar and parodied in some ways to the Thing, Xenomorphs and The Blob as it is a parasitic life-form that exists under the ground but becomes deadly once eaten and will grow to the point of killing its host: it is also extremely addictive and can take control of its victims' minds, forcing them to attack those that would seek to harm to it.
The Stuff also has a strange and very sweet taste that humans seem to enjoy - this made The Stuff especially dangerous as it was mistakenly sold as a foodstuff and even an ice cream by unwary businesses, resulting in the deadly substance being unleashed upon an unsuspecting public: with gruesome results.
The Stuff is the titular villain of the movie but the true antagonists are arguably Mr. Evans and Mr. Fletcher - two rival businessmen who were willing to sell the Stuff in order to profit of its addictive properties despite knowing of its deadly origins.