As the name implies, they are a cheap knock-off parody of the 1960s English singing group The Beatles, which the creator Craig McCracken is a fan of.
When the villains Mojo Jojo, HIM, Fuzzy Lumpkins, and Princess Morbucks pinned the Powerpuff Girls with a boulder, they discovered that together they could be unstoppable. So together, they formed the Beat-Alls.
The Powerpuff Girls were no match for their teamwork attacks, so the girls used a chimp named Michelle (under the name of Moko Jono, a parody of the late John Lennon's widow Yoko Ono) to get Mojo Jojo to fall in love so that the team would have to disband. Eventually, the team disbanded because they couldn't stand Mojo being in love with Moko. Soon after, a zookeeper named Judy unmasks Moko as Michelle, revealing that the girls used Michelle to mislead Mojo out of the band. When Judy left with Michelle, the girls take the crestfallen Mojo to jail with the rest of the band.
They only appeared as an onscreen team on "Meet the Beat-Alls".
- The team name is a cheap rip-off pun of the British rockband "The Beatles".