Pinky: Gee Brain, what do you want to do tonight?
Brain: The same thing we do every night, Pinky: Try to take over the world!
~ The Brain to Pinky almost every episode (also their most famous lines.)
Pinky, are you pondering what I'm pondering?
~ The Brain asking Pinky if they are thinking the same thing (only to always get an idiotic response).

The Brain (also known as Brain) is the main antagonist of Animaniacs, the prantagonist villain of its spinoff Pinky and the Brain and Pinky, Elmyra and the Brain, and the main antagonist of the crossover series The Plucky Duck Italian Adventures.

The Brain is a lab-mouse who, upon being mutated in an experiment, gained superhuman intelligence and desired to take over the world in order to make it a better place. However, despite his numerous claims of success, Brain never ends up succeeding at his end goals, both due to his idiotic partner Pinky and, in some ways, himself.

In the original series and the 2020 reboot, he is voiced by Maurice LaMarche, who also played Lrrr, Morbo and The Big Brain in Futurama, Father in Codename: Kids Next Door, Alec Baldwin in Team America: World Police, Mr. Big in Zootopia, Mortimer Mouse in the Mickey Mouse franchise and sometimes Yosemite Sam in the Looney Tunes franchise.


Both Brain and Pinky are laboratory mice who underwent an experiment to make them rational. The experiment had different results on each of them, turning Brain into a super genius, while Pinky also becomes sentient but incredibly stupid. Brain then decided he would use his superior knowledge to take over the world and make it a better place using his intellect. He convinced Pinky to aid him in his plans, and the two of them try a new plan to achieve world domination every night.


Brain is a manipulative genius with a calm and overconfident personality. He almost never loses his cool: when Pinky's clumsiness spoils his plans completely, Brain's only reaction is a brief annoyance. He also seems to be egocentric and arrogant in nature. Despite his desire to conquer the world, he truly believes he is doing it so he can make it a better place, and will never resort to murder to accomplish his goals. He does care about Pinky, even though he abuses and threatens him constantly.

There are some world domination plans he refuses to attempt: for instance, he was unwilling to use a plan selling cigarettes to children. Brain's good intentions are emphasized by his rivalry with Snowball, a hamster who also planned to conquer the world, but proved far more cruel. Brain is disgusted by Snowball's methods and goes so far as to save the world from him.

He also loves Billie, a female mouse who loves Pinky more than Brain.



  • Brain's voice and character were largely inspired by famous actor/director Orson Welles, whom his voice actor, Maurice LaMarche, would often listen to while warming up. In fact, the Animaniacs short "Yes, Always", in which Brain and Pinky were hired to provide voice work for an episode of Animaniacs, was a direct parody of an infamous audio recording in which Welles heavily criticized the mediocre writing and directing of several commercials he was to voice over, with Brain quoting his complaints word for word.
  • Only one of Brain's plans succeeded. He used time travel to provide Fire to Mousekind before Mankind could discover it.
    • The reasoning is that Fire is the First One advantage Man had which placed them at the top of the Food Chain. Upon returning to the "present", Mousekind was indeed the dominant species on the planet. The drawback was each and everyone they saw were just like Pinky, right down to the "Narf!" catchphrase, forcing Brain to remove the changes he made to history, as, although he could rule the world, he did not want to.


           Looney Tunes Logo.png Villains

Looney Tunes/Merrie Melodies
Daffy Duck | Elmer Fudd | Lawyer Goodwill | Adolf Hitler | Cecil Turtle | Beaky Buzzard | Cottontail Smith | Von Vultur | Schultz | Henery Hawk | Dan Backslide | Gremlin | Sylvester | Papa Bear | Yosemite Sam | Gossamer | Barnyard Dog | The Crusher | Marvin the Martian | K-9 | Wile E. Coyote | ACME | Nasty Canasta | Pete Puma | Weasel | Egghead Jr. | Rocky and Mugsy | Ralph Wolf | Napoleon Bonaparte | Shropshire Slasher | Tasmanian Devil | Witch Hazel | Robot | Instant Martians | Blacque Jacque Shellaque | Count Bloodcount | Bunny and Claude | Bunny Snatchers

Who Framed Roger Rabbit
Judge Doom | Toon Patrol (Smartass, Greasy, Psycho, Wheezy & Stupid)
Space Jam
Mr. Swackhammer | Monstars
Looney Tunes: Back In Action
Mr. Chairman | Bob Smith | Daffy Duck | Elmer Fudd | Sylvester | Marvin the Martian | Yosemite Sam | Nasty Canasta | Cottontail Smith | Wile E. Coyote | ACME

Tiny Toon Adventures
Montana Max | Elmyra Duff | The Brain | Sweetie Bird | Mr. Hitcher | Big Daddy Boo | Johnny Pew | Adults Against Funny Cartoons Chairperson | Duck Vader | Ronald Grump | Tad the Imaginary Friend | Rhoda Queen | Arnold the Pit Bull | Dr. Gene Splicer | Eddy Cougar | Roderick & Rhubella Rat | The Wolverine | Gotcha Grabmore | Amby and Floyd | Boss Tick | Barbette | Foghorn Draghorn | Sappy Stanley | Evil Talking Cake | Silas Wonder | Knuckles Cutlet | Danforth Drake & Margot Mallard | S.N.I.D.E. | Swan Dancers
Animaniacs/Pinky and the Brain
The Brain | Katie Ka-Boom | Count Dracula | Satan | Walter Wolf | Sid the Squid | Beanie the Bison | Buddy | King Salazar | Fermin Flaxseed | Snowball | Precious | Wally Faust
Tasmanian Devil | Bull and Axle
Duck Dodgers
Duck Dodgers | Martian Commander X-2 | Martian Queen | Martian General Z-9 | Happy Cat (Duck Dodgers)
Loonatics Unleashed
Ringmaster & Otto the Odd | General Deuce | Electro J. Fudd | Optimatus | Massive | Black Velvet | Sylth Vester | Drake Sypher | Weather Vane | Mastermind | Rip Runner | Rupes Oberon | Dr. Dare | Ophiuchus Sam | Pierre Le Pew | Melvin the Martian | Boötes Belida | Adolpho | Stoney and Bugsy | Pinkster Pig
Daffy Duck | Elmer Fudd | Sylvester | Yosemite Sam | Gossamer | Barnyard Dog | Marvin the Martian | Top Salesman | Dr. Zarius | Carrot Monster
The Looney Tunes Show
Daffy Duck | Elmer Fudd | Tasmanian Devil | Sylvester | Yosemite Sam | Marvin the Martian | Wile E. Coyote | Pete Puma | Gossamer | Henery Hawk | Cecil Turtle | Zod Duck | K-9 | Instant Martians | Witch Hazel | Colonel Frankenheimer | Barnyard Dog | Blacque Jacque Shellaque | The Crusher | Shropshire Slasher | Nasty Canasta | Rocky and Mugsy
Wabbit-New Looney Tunes
Daffy Duck | Elmer Fudd | Wile E. Coyote | Yosemite Sam | Carl the Grim Rabbit | Viktor | Claudette Dupri | Hazmats | Foxy Foxworth

Guest Villains
Monstars | Metaluna Mutant | The Man from Planet X | Edward Hyde | Judge Doom | Mr. Chairman | Wicked Witch of the West | Mr. Swackhammer | Daleks

Community content is available under CC-BY-SA unless otherwise noted.