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How about I throw him a fundraiser on the Riverboat? Show him a real nice time, get him laid, all that shit. I'll pick the "guests" myself, make sure they know what's what. Then we'll take a nice long cruise down the Bayou. Once he sees that payday, Jacobs is gonna do whatever we want.
~ Uncle Lou

Louis "Lou" Marcano, better known as Uncle Lou, is a major antagonist in the 2016 videogame Mafia III. He is Sal Marcano's older brother and a Caporegime in the Marcano Crime Family, and the man in charge of the family's rackets and businesses in the French Ward, along with their political relations.

He was voiced by Brad Leland, who also played Calhoun Schrier in Justified.



The oldest Marcano brother, Lou was born in 1909. He had three brothers, Salvatore, Lucio, and Thomas, and one sister. Of the five siblings, Lou was the eldest. The Marcano brothers' early years were marked by poverty as their father Valerio struggled to feed the family by working as an enforcer for the Carillo crime family. The family lived in a shanty on the outskirts of River Row. Valerio was a compulsive gambler, running up big debts and oftentimes gambling away much of his meager income, which added to the family's poverty. The Marcano brothers had been juvenille delinquints from a young age, soon following their father into full-time criminal work doing small time jobs. While the three elder brothers were committing a crime in the French Ward, they were caught and convicted of breaking & entering. All three were sentenced to a term in Cordoba State Penintentiary. The only one of the Marcano brothers who was not thrown in jail was Tommy. It was likely that due to his young age he was excluded from the crime spree, as he still had yet to graduate from elementary school when his brothers went up the river.

Following their release from prison, they joined their father in working for the Carillo Crime Family, the most powerful criminal organization in New Bordeaux. Lou decided to dabble in drugs, making small-time deals selling cocaine on the streets. In 1934, Valerio's gambling debts had caught up with him, and his creditors wanted payment in blood if not in cash. Valerio was found dead. That same year, the three eldest Marcano brothers along with two other allies, one of them being Enzo Conti, gunned down Don Carillo and his lieutenants while they were dining in a restaurant in the French Ward. It was later revealed that Don Guiseppe Carillo had been released from Cordoba State Penintentiary prior to this and had been the cellmate of Sal Marcano. Sal had saved Don Carillo from getting shanked during a prison riot. Carillo offered to show his gratitude to Sal by wiping his father's gambling debts clean. Sal declined, claiming his father had to pay up, and Valerio was murdered shortly afterwards. Sal then lied to Lucio and Lou that they needed to enact revenge, hence the massacre. 

The Marcanos took over after that as the most powerful criminals in the city, and from the remains of the Carillo family, founded the Marcano Crime Family. Lou then set up drug and prostitution rackets in the French Ward district, that proved extremely lucrative and brought the family a lot of money. He also blackmailed and paid most of the influential politicians and city officials, who would turn a blind eye to the Marcanos' activities.

He also carefully developed a public personality known as "Uncle Lou", the owner of a chain of popular and successful restaurants and pubs in the French Ward and the "unofficial mayor" of New Bordeuax. He attracted tourists and citizens of the city to the French Ward with radio advertisements and along with Remy Duvall, was one of the biggest radio personalities of the city. In 1965, Lou worked with the New Bordeaux Chamber of Commerce in filming a travel video extolling the city and encouraging Americans to spend their next family vacation there.

Lou's rackets made big money because the French Ward, while being a welcoming, safe and fun place in the public eye, was also where the wealthiest and corrupt citizens of New Bordeaux could come to "fuck and get high".  With his legal businesses, he had cultivated the "jolly fat man" persona which was used by Southern businessmen running establishments open to people of all ages. Examples included radio spots where he offered to buy a round of whiskey if you bumped into him around town, or have children eat free at his restauarants if the parents were also ordering off the menu. With his illegal businesses, he had engaged in a risky venture which paid off well, getting both drugs and prostitution to tourists who had less disposable income that VIPs whom such rackets normally catered to.  As Lou put it himself "Everyone can get high or stoked, and you can tickle your pickle whether you spend $20 or $25,000." This paid off handsomely for Lou, as it did not matter if the client was a high school student from Illinois or a high-roller from Pennsylvania, Lou had dope and pussy at an affordable price.

Lou's right-hand man and accountant was Tony Derazio, who managed Lou's political alliances and finances, as well as the whole family's finances and ledges.

Mafia III

Getting Political Allies

In 1968, Sal was building an ambitious casino by the city's river, and he was counting on Lou to make sure that they have a political ally legalize gambling for them. He had Tony search for a trustworthy man on this, and Tony found Cornelius Holden, a crooked and wealthy judge. Lou quickly contacted Holden and made a deal with him, providing him with booze, drugs and women, while receiving political information and favors in return.

However, that same year, Sal had eliminated an old allied gang of theirs, the Black Mob. One of the members of the mob, Lincoln Clay, survived and waged war on the Marcanos. News of the attacks had been noticed by Lou's underlings, of which Lou correctly deduced that Lincoln Clay was still alive. One day when Sal Marcano was convincing his son that their future was in the casino, Lou called his brother to give this report, which meant that Sal was now aware of Clay's survival and subsequent vendetta. Shortly after, Lincoln went after Tony and put and end to the bookkeeper's rackets in Downtown. Lou then called Tony and warned him of Lincoln's voracity and skill, and ordering him to replace the extortionists and puppets Lincoln eliminated in Downtown, and Tony assured him that would be done quickly. However, only minutes later, Lincoln confronted Tony and tossed him off the penthouse window of the Royal Hotel.

With Tony dead, Lou was weakened, but he still was not toothless. While the Marcanos lost a brilliant accountant, they had other aces up their sleeve. Also delaying the vendetta was that Derazio had not directly exposed Lou's relationship. When Derazio recorded a kickback, he coded his ledger, in this case to Holden as "USCCJ5". John Donovan correctly surmised that this was a judge on the U.S. Fifth Circuit. However, he warned Lincoln this was going to take time to uncover, as a circuit court often has about twenty judges who rotate on the bench.


Lincoln went to the French Ward and took over Lou's rackets while taking care of Lou's two racketeers, Handsome Harry and Doc Gaston. After that, Lincoln learnt of Judge Holden and went after him. Sensing this, Lou called Holden and informed him of the danger, being received with anger and fear from the judge, and Lou then sent a squad of his best men to protect Holden. This was fruitless however, as Lincoln ambushed and murdered Holden.

With Holden dead, the family was short of powerful political allies since Tony was in charge of the political extortion and Holden was their most influential acquaintance. Lou met Sal and while being harshly treated by his brother due to Lincoln's actions, he assured him that the situation would be fine, telling Sal that he found another political acquaintance, Senator Walter Jacobs. Sal warned Lou that this better go successfully, and Lou told Sal he'd throw a fundraiser and get Jacobs laid with whores to make the senator obey them.


Amidst the fundraiser, which was being held on Lou's riverboat, the Delphine, on the Bayou, Lincoln blew up a nearby barrage and blocked Lou's way, severely damaging and causing a fire on Lou's riverboat in the process. Lou then ordered his men to kill the perpetrator, and went with Jacobs to the boat's top balcony.

Lou also prevented the Riverboat's captain from deploying the lifeboats to help people escape, saying that if he was going to die, they were all going to die with him. Lincoln shot his way to Lou and confronted him on the balcony, with Lou holding Jacobs hostage and saying that another step and he gets it. Lincoln tells Lou that he doesn't "give a shit" about some politician, and only seconds later, the riverboat collides with the destroyed barrage. Shortly after, the boat blows up and sends both Lincoln and Lou flying through the Bayou, while Jacobs dies amidst the explosion.

A extremely wounded Lou then tries to escape Lincoln throughout the Bayou's shallow waters, but tires off and stops at a bench to recover from the adrenaline. However, Lincoln sneaks behind Lou and subdues him, holding him hostage with a knife. Lou tries to convince Lincoln not to kill him by offering him money, but Lincoln tells him that he doesn't want his money, he wants Lou to send a message to Sal.

Lou then gladly agrees to this and begs Lincoln to say the message. Lincoln then holds a knife to Lou's throat and drags him away into the wooded area of the bayou, where the screen fades to black. It then lights up again in the General's Circle section of the city, where Lou's dead body is seen hanging from a statue of Andrew Jackson, and a crudely-made sign that has "Re-Elect Jacobs" in handwritten block lettering is hanging from Lou's neck.



  • Uncle Lou is the eldest of the Marcano brothers. Dependent on which order he was killed in, the scene where Sal Marcano learns of his death will be different. For example, if he is the first capo to be killed, Giorgi Marcano will suggest trying to blackmail the governor, only for Sal to lack confidence. Whichever order he is killed, be it first, second, or third, Sal will say each time to his son "Lou is dead; gutted like a catfish".
  • The man who first notices Uncle Lou's corpse was also in the first scene of the game, welcoming Lincoln Clay home from Vietnam and saying that he himself was a Marine who fought in the Second World War.


               Mafialogo.png Villains

Tommy Angelo | Ennio Salieri | Sam | Paulie | Don Morello | Sergio Morello Jr. | Louie | Vito Scaletta | Joe Barbaro

Mafia II
Vito Scaletta | Joe Barbaro | Leo Galante | Henry Tomasino | Carlo Falcone | Brian O'Neill | Derek Pappalardo | Frank Vinci | Alberto Clemente | Eddie Scarpa | Luca Gurino | Steve Coyne | Sidney Pen | Mickey Desmond | Zhe Yun Wong

Mafia II: Joe’s Adventures
Joe Barbaro | Rocco

Mafia II: The Betrayal of Jimmy and Mafia II: Jimmy's Vendetta
Jimmy | Elroy Tussle | Eddie Fu | Sal Gravina | Judge Hillwood

Mafia III
Lincoln Clay | John Donovan | Cassandra | Thomas Burke | Vito Scaletta | Joe Barbaro | Leo Galante | Marcano Crime Family | Sal Marcano | Giorgi Marcano | Uncle Lou | Tommy Marcano | Olivia Marcano | Roman Barbieri | Tony Derazio | Michael Grecco | Frank Pagani | Nino Santangelo | Enzo Conti | Ritchie Doucet | Remy Duvall | Cornelius Holden | Walter Jacobs | Baka

Mafia III: Faster, Baby!
Lincoln Clay | Walter Beaumont

Mafia III: Stones Unturned
Lincoln Clay | John Donovan | Connor Aldridge

Mafia III: Sign of the Times
Lincoln Clay | Bonnie Harless

Mafia: Definitive Edition
Tommy Angelo | Ennio Salieri | Sam Trapani | Paulie Lombardo | Don Morello | Sergio Morello Jr. | Lou | Dino | Vito Scaletta | Joe Barbaro