I'll see if this page can be created but for now I'll put it in a blog, because often when researching a series I find a hard time figuring out who the main villain is (often because some wikis refuse to say things like "main villain" or "main antagonist")
Spoilers will have their own section. If there is a spoiler villain in a single season of a show, I'll say "spoiler" and list them there. Otherwise (like Scream) I'll list the series separately. Note that villains who aren't revealed to be bad in a single episode but are known for the remainder of the series will be listed in the main section (like the main villain of Burn Notice), this is only for those who aren't revealed until the end
Note that some may be missing, incase I haven't seen them or forgot. If this can become an actual page, others could add to it, but so far no one seems to have answered my forum request to return the Yu-Gi-Oh villains' pages to their English names
I haven't played Donkey Kong (besides the original where he's the villain), F-Zero, Mother, Ice Climber, Fire Emblem, Kid Icarus, Metal Gear, Mega Man, Xenoblade, Street Fighter, Castlevania, Final Fantasy, Splatoon, or Bayonetta, but I did research them out of curiosity of all the game series the Super Smash Bros. Ultimate characters are from.
Updated Friday December 13th, 2019
Main
10,000 BC
- The Almighty
101 Dalmatians
- Cruella De Vil
24
- Season 1 - Victor Drazen
- Season 2 - Peter Kingsley, Max (Bigger Bad)
- Season 3 - Ramon Salazar, Stephen Saunders
- Season 4 - Habib Marwan
- Season 5 - (spoiler), Vladimir Bierko, Graem Bauer (Bigger Bad)
- Season 6 - Abu Fayed, Cheng Zhi, Phillip Bauer
- Season 7 - Alan Wilson
- Season 8 - Samir Mehran, Charles Logan, Yuri Suvarov
- Live Another Day - Margot Al-Harazi, Cheng Zhi
3 Days to Kill
- The Wolf
The 6th Day
- Michael Drucker
6 Underground
- Rovach Alimov
Abbott and Costello Meet Frankenstein
- Count Dracula
Abduction
- Nikola Kozlow
A Bug's Life
- Hopper
The Adventures of Brisco County Jr.
- John Bly
The Adventures of Robin Hood
- Prince John
The Adventures of Sharkboy and Lavagirl
- Minus
- Mr. Electric (final)
Aeon Flux
- Oren Goodchild
Agent Cody Banks
- Dr. Brinkman
Air Force One
- Ivan Korshunov
Aladdin
- Aladdin - Jafar
- The Return of Jafar - Jafar
- Aladdin and the King of Thieves - Sa'luk
Alice in Wonderland
- The Red Queen
Alien
- Alien - Xenomorph
- Aliens - Xenomorph Queen
- Alien 3 - Dog Xenomorph
- Alien Resurrection - Clone Xenomorph Queen
American Assassin
- Ghost
A Million Ways to Die in the West
- Clinch Leatherwood
Anaconda
- Paul Serone
- Anaconda
Anastasia
- Rasputin
A Nightmare on Elm Street
- Freddy Krueger
Antz
- General Mandible
The Aristocats
- Edgar
Arrowverse
- Arrow:
- Season 1 - Malcolm Merlyn
- Season 2 - Slade Wilson
- Season 3 - Ra's Al Ghul
- Season 4 - Damien Darhk
- Season 5 - Adrian Chase
- Season 6 - Ricardo Diaz
- Season 7 - Longbow Hunters
- The Flash:
- Season 1 - Reverse Flash
- Season 2 - Zoom
- Season 3 - Savitar
- Season 4 - Clifford DeVoe
- Season 5 - Cicada
- Legends of Tomorrow:
- Season 1 - Vandal Savage
- Season 2 - Reverse Flash (time remnant)
- Season 3 - Mallus
- Season 4 - Neron
Atlantis
- The Lost Empire - Rourke
- Milo's Return - Kraken, Ashton Carnaby, Erik Hellstrom
Ator, the Fighting Eagle
- Dakkar
- The Ancient One (Bigger Bad)
Austin Powers
- Dr. Evil
Avatar
- Colonel Miles Quaritch
Babes in Toyland
- Barnaby
Babes in Toyland (animated)
- Barnaby Crookedman
- Goblin King
Back to the Future
- Back to the Future - Biff Tannen
- Back to the Future II - Biff Tannen
- Back to the Future III - Buford "Mad Dog" Tannen
Bad Times at the El Royale
- Billy Lee
Balls of Fury
- Feng
Batman (Tim Burton series)
- Batman - The Joker
- Batman Returns - The Penguin (some might also count Max Shreck and Catwoman)
- Batman Forever - Two-Face, the Riddler
- Batman & Robin - Mr. Freeze, Poison Ivy
Batman (TV series)
- The Penguin
- The Joker
- The Riddler
- Catwoman
Bayonetta
- Bayonetta - Father Balder (though technically he's being manipulated by Loptr), Jubileus the Creator
- Bayonetta 2 - Loptr
Beast Wars/Beast Machines
- Megatron
Beauty and the Beast
- Gaston
Benchwarmers
- Fairy Jerry
Beverly Hills Cop
- Victor Maitland
Big Fat Liar
- Marty Wolf
Big Trouble in Little China
- David Lo Pan
Bionicle
- Bionicle 2: Legends of Metru Nui - Makuta
- Bionicle 3: Web of Shadows - Roodaka
- Bionicle: Mask of Light - Makuta
The Black Cauldron
- The Horned King
Black Lagoon
- Episodes 1-2 - EO Captain
- Episode 3 - Mr. Shin
- Episodes 4-6 - Ratchman
- Episodes 8-10 - Roberta
- Episodes 11-12 - Ibraha
- Episodes 13-15 - Hansel and Gretel
- Episodes 16-18 - Groovy Guy Russell
Blade
- Blade - Deacon Frost
- Blade II - Jared Nomak
- Blade Trinity - Drake
Blazing Dragons
- Count Geoffrey
Bomberman
- Bomberman 64 - Altair, (spoiler) (final)
- Bomberman 64: The Second Attack - Sthertoth
- Bomberman Hero - Bagular, Evil Bomber (Bigger Bad)
The Boondock Saints
- The Boondock Saints - Giuseppe "Pappa Joe" Yakavetti
- The Boondock Saints II: All Saints Day - The Old Man
Bones
- Season 3 - Gormogon
- Season 6 - Jacob Broadsky
- Season 7 - Christopher Pelant
- Season 8 - Christopher Pelant
- Season 11 - The Puppeteer
- Season 12 - Mark Kovac
The Bourne Identity
- Carlos
(Note: I didn't see the reboot series, which is harder to follow and deviated from the books so hard that they had to wait for the book's writer to die coz they knew he'd never approve it)
Broken Arrow:
- Vic Deakins
Bubble Bobble
- Bubble Bobble - Super Drunk (main), Boss of Dark Shadow (Bigger Bad)
- Rainbow Islands - Boss of Dark Shadow
- Bubble Bobble 2 - Red Skull Brother (Boss of Dark Shadow reincarnated)
Buffy the Vampire Slayer
- Season 1 - The Master
- Season 2 - Drusilla, Angelus
- Season 3 - Mayor Wilkins
- Season 4 - Adam
- Season 5 - Glory
- Season 6 - Warren Mears
- Season 7 - The First
Angel (which is its own show but still part of the Buffyverse)
- Series - The Senior Partners
- Season 2 - Darla (vampire)
- Season 3 - Daniel Holtz, Sahjhan (Bigger Bad)
- Season 4 - Jasmine
Burn Notice
- Seasons 1-4 - Management
- Seasons 1-6 - Anson Fullerton
- Seasons 3 and 4 - John Barrett
- Season 6 - Tom Card, Olivia Riley
- Season 7 - James Kendrick
Buzz Lightyear of Star Command
- Emperor Zurg
Caillou
- Caillou
Castle in the Sky
- Colonel Muska
Castlevania
- Dracula
Cats Don't Dance
- Darla Dimple
Charlie and the Chocolate Factory
- Mike Teavee
Charmed
- Seasons 1-3 - The Source of All Evil
- Season 4 - The Source of All Evil, Cole Turner (Source half), The Seer
- Season 5 - Cole Turner
- Season 6 - Gideon
- Season 7 - Zankou
- Season 8 - The Triad
Child's Play
- Chucky
Clash of the Titans
- Hades
Clockstoppers
- Henry Gates
Cloudy with a Chance of Meatballs
- Cloudy with a Chance of Meatballs - Mayor Shelbourne
- Cloudy with a Chance of Meatballs 2 - Chester V
Colombiana
- Don Luis
The Color of Magic
- Ymper Trymon
Commando
- Arius
Con Air
- Cyrus the Virus
Conan the Barbarian
- Conan the Barbarian - Thulsa Doom
- Conan the Destroyer - Queen Taramis, Dagoth (final)
Contra
- Java, Gomeramos King
The Count of Monte Cristo
- Fernand Mondego
Crocodile Dundee
- Crocodile Dundee II - Luis Rico
The Crocodile Hunter: Collision Course
- Department Director Ansell
Cross Ange
- Embryo
The Curse of King Tut's Tomb
- Morgan Sinclair, Nathan Cairns (Bigger Bad), Set (final)
Custom Robo
- Oboro
- Eliza
- Rahu
Cypher
- Finster
- Frank Callaway
Date Movie
- Andy
DC Extended Universe
- Wonder Woman - Ares
- Man of Steel - General Zod
- Batman vs. Superman - Lex Luthor
- Suicide Squad - Enchantress
- Justice League - Steppenwolf, Darkseid (Bigger Bad)
Dead Space
- Dead Space - Necromorphs
- Dead Space II - Hans Tiedemann
- Dead Space III - Jacob Danik
Death Note
- Light Yagami
Death Race 2000
- Mr. President
Deja Vu
- Carroll Oerstadt
Delgo
- Sedessa
Demolition Man
- Simon Phoenix
Despicable Me
- Despicable Me - Vector
- Despicable Me 2 - (spoiler)
Dick Tracy
- Big Boy
Die Hard
- Die Hard - Hans Gruber
- Die Hard II - Colonel Stuart
- Die Hard with a Vengeance - Simon Gruber
- Live Free or Die Hard - Thomas Gabriel
Digimon
- Season 1 Arc 1 - Devimon
- Season 1 Arc 2 - Etemon
- Season 1 Arc 3 - Myotismon
- Season 1 Arc 4 - MetalSeadramon, Puppetmon, Machinedramon, Piedmon
- Season 1 Arc 5 - Apocalymon
- Digimon: The Movie - Diaboromon, Kokomon (non-canon segment)
- Season 2 - (spoiler, though I think that season's non-canon)
Digimon Tamers
- Arc 1 - Mitsuo Yamaki
- Arc 2 - Zhuqiaomon
- Battle of Adventurers - Mephistomon
- Arc 3 - Zhuqiaomon
- Arc 4 - D-Reaper
- Runaway Locomon - Parasimon
Digimon Frontier
- Arc 1 - Cherubimon
- Arc 2 - Lucemon
Dinosaur
- Kron
- Carnotaur
Divergent
- Divergent - Jeanine Matthews
- The Divergent Series: Insurgent - Jeanine Matthews
- The Divergent Series: Allegiant - David
DoA: Dead or Alive
- Victor Donovan
Dogma
- Bartleby
- Azrael
Donkey Kong (in continuity with Mario)
- King K. Rool
Down Periscope
- Admiral Graham
Dracula (1979)
- Count Dracula
Dracula (Hammer)
- Count Dracula
Dracula (Coppola movie)
- Count Dracula
Dragonball
- Emperor Pilaf
- Commander Red
- King Piccolo
Dragonball Z
- Frieza
- Cell
- Super Buu/Kid Buu
- Including one-shots:
- Dead Zone - Garlic Jr.
- Saiyan Saga - Vegeta
- Namek Saga - Vegeta, Frieza
- Captain Ginyu Saga - Frieza
- Frieza Saga - Frieza
- Garlic Jr. Saga - Garlic Jr.
- Trunks Saga - Frieza, King Cold
- Androids Saga - Dr. Gero, Androids 17 and 18
- Imperfect Cell Saga - Cell
- Perfect Cell Saga - Cell
- Cell Games Saga - Cell
- World Tournament Saga - Babidi (though it's mainly Spopovich working for him)
- Babidi Saga - Babidi
- Majin Buu Saga - Majin Buu
- Fusion Saga - Super Buu
- Kid Buu Saga - Kid Buu
- Dragonball Z Kai
- Arc 1 - Frieza
- Arc 2 - Cell
- Arc 3 - Evil Buu
Dragonball Evolution
- King Piccolo
Dragonball Z movies (not counting canon ones)
- The World's Strongest - Dr. Wheelo
- The Tree of Might - Turles
- Lord Slug - Lord Slug
- Cooler's Revenge - Cooler
- The Return of Cooler - Cooler
- Super Android 13 - Android 13
- Broly: The Legendary Super Saiyan - Broly
- Bojack Unbound - Bojack
- Broly: Second Coming - Broly
- Bio-Broly - Bio-Broly
- Fusion Reborn - Janemba
- Wrath of the Dragon - Hirudegarn, Hoy (Bigger Bad)
- Battle of Gods - Beerus
- Resurrection F - Frieza
Dragonheart:
- Dragonheart - King Einon
- Dragonheart: A New Beginning - Griffin
Dredd
- Ma-Ma
Drive Angry
- Jonah King
DuckTales the Movie
- Merlock the Magician
Dune
- Baron Vladimir Harkonnen
- Emperor Shaddam IV
Eagle Eye
- Ariia
Earthsea
- King Tygath
Edge of Tomorrow
- Omega
Eight-Legged Freaks
- Consuela
Elektra
- Kirigi
Elysium
- Secretary Delacourt
- (spoiler)
The Emperor's New Groove
- Yzma
Enchanted
- Queen Narissa
Enter the Dragon
- Han
Enter the Warriors Gate
- Arun the Cruel
Epic Movie
- White Bitch
The Equalizer
- The Equalizer - Vladimir Pushkin (though some might consider him Bigger Bad and call Nicolai Itchenko the main villain)
- The Equalizer 2 - (spoiler)
Eragon
- King Galbatorix
Eternal Darkness
- Pious Augustus
- Chattur'gha
- Ulyaoth
- Xel'lotath
Evil Dead
- Evil Ash (who I think is the Evil Force merged with Ash's dark side)
The Expendables
- The Expendables - James Munroe
- Expendables 2 - Jean Vilain
- Expendables 3 - Conrad Stonebanks
Face/Off
- Castor Troy
Fantastic Four
- Series - Doctor Doom
- Fantastic Four: Rise of the Silver Surfer - Galactus
Fantastic Four (reboot)
- Doctor Doom
Fantastic Mr. Fox
- Boggis, Bunce, and Bean
The Fast and the Furious
- The Fast and the Furious - Johnny Tran
- 2 Fast 2 Furious - Carter Verone
- The Fast and the Furious: Tokyo Drift - Takashi
- Fast & Furious - Arturo Braga (works for Owen)
- Fast Five - Hernan Reyes
- Fast & Furious 6 - Owen Shaw (works for Cipher)
- Furious 7 - Deckard Shaw
- The Fate of the Furious - Cipher
- Hobbs & Shaw - Brixton Lore (main), Eteon Director (Bigger Bad)
The Fifth Element
- Mr. Shadow
Final Fantasy
- Final Fantasy - Garland
- Final Fantasy II - Emperor Mateus
- Final Fantasy III - Cloud of Darkness
- Final Fantasy IV - Zemus
- Final Fantasy V - Exdeath
- Final Fantasy VI - Kefka Palazzo
- Final Fantasy VII - Sephiroth
- Final Fantasy VIII - Ultimecia
- Final Fantasy IX - Kuja
- Final Fantasy X - Yu Yevon
- Final Fantasy XII - Vayne Solidor
- Final Fantasy XIII - Galenth Dysley
- Final Fantasy XV - Ardyn Izunia
Final Fantasy: The Spirits Within
- Phantoms
- General Hein
Fire Emblem
- Fire Emblem - Nergal
- The Sacred Stones - Fomortiis
- Path of Radiance - Ashnard
- Radiant Dawn - Sephiran
- Awakening - Grima
- Fates - Anankos (Revelations route, considered true ending; Birthright and Conquest endings have King Garon as the villain)
- Shadow Dragon - Medeus
Firefly
- The Parliament
First Knight
- Prince Malagant
Flash Gordon
- Ming the Merciless
The Flight of Dragons
- Ommadon
Flubber
- Chester Hoeincker
Friday the 13th
- Friday the 13th - Pamela Voorhees
- Friday the 13th Parts 2-4 - Jason Voorhees
- Friday the 13th Part V: A New Beginning - (spoiler)
- Friday the 13th Parts 6-9 - Jason Voorhees
- Freddy vs. Jason - Freddy Krueger, Jason Voorhees
- Jason X - Jason Voorhees
Fullmetal Alchemist
- Series - (spoiler)
- Conqueror of Shambala - Dietlinde Eckhart
F-Zero
- F-Zero - Black Shadow
- F-Zero X - Black Shadow
- F-Zero GX - Deathborn
Galaxy Quest
- Sarris
Game of Thrones
- Season 1 - Cersei Lannister, Joffrey Baratheon
- Season 2 - Joffrey Baratheon, Tywin Lannister, Melisandre, Mance Rayder, Theon Greyjoy, Balon Greyjoy (Bigger Bad)
- Season 3 - Joffrey Baratheon, Tywin Lannister, Melisandre, Mance Rayder
- Season 4 - Tywin Lannister, Melisandre, Mance Rayder
- Season 5 - The High Sparrow, Roose Bolton, Ramsay Bolton, Melisandre, Belicho, Razdal, Yezzan, the Night King
- Season 6 - The High Sparrow, Ramsay Bolton, Belicho, Razdal, Yezzan, the Night King
- Season 7 - Cersei Lannister, the Night King
- Season 8 - Cersei Lannister, the Night King, (spoiler)
Gamer
- Ken Castle
George of the Jungle
- Lyle van de Groot
Get Shorty
- Bo Catlett
- Ray Bones
Gex
- Rez
Ghost Rider
- Ghost Rider - Blackheart
- Ghosr Rider 2: Spirit of Vengeance - Roark (Mephistopheles)
Ghostbusters
- Gozer
Gladiator
- Commodus
Glitter Force
- Emperor Nogo
The Godfather
- The Godfather - Virgil Solozzo, Emilio Barzini
- The Godfather Part II - Hyman Roth
- The Godfather Part III - Licio Lucchesi
God of War
- Ares
The Good, the Bad, and the Ugly
- Angel Eyes
The Great Mouse Detective
- Professor Ratigan
Gremlins
- Gremlins - Stripe
- Gremlins 2: The New Batch - Brain Gremlin, Mohawk
Gundam Wing
- Series - Treize Khushrenada
- Romefeller arc - Duke Dermail
- Endless Waltz - Dekim Barton
Halloween
- Michael Myers
- Dr. Wynn (Bigger Bad)
Halloween 3: Season of the Witch
- Conal Cochran
Hamlet
- King Claudius
Hannibal
- Red Dragon - Francis Dolarhyde
- The Silence of the Lambs - Buffalo Bill
- Hannibal - Mason Verger
Harry Potter
- Series - Lord Voldemort
- Order of the Phoenix - Dolores Umbridge
Hellboy
- Hellboy - Grigori Rasputin
- Hellboy II: The Golden Army - Prince Nuada
Hellraiser
- Hellraiser - Frank Cotton
- Hellbound: Hellraiser II - Dr. Channard
- Hellraiser III: Hell on Earth - Pinhead
- Hellraiser Inferno - Pinhead
- Hellraiser Hellseeker - Pinhead
- Hellraiser Deader - Winter
- Hellraiser Bloodline - Pinhead
Hercules
- Hades
Hercules Against the Moon Men
- Redolphis
Heroes
- Volume 1 - Sylar, Daniel Linderman
- Volume 2 - Adam Monroe
- Volume 3 - Arthur Petrelli
- Volume 4 - Emile Danko
- Volume 5 - Samuel Sullivan
- Heroes Reborn - Erica Kravid
Highlander
- The Kurgan
His Dark Materials
- Mrs. Coulter
Hobbs & Shaw
- Brixton Lore (main), Eteon Director (Bigger Bad)
Hollow Knight
- The Radiance
Home Alone
- Home Alone - Harry and Marv
- Home Alone 2: Lost in New York - Harry and Marv
- Home Alone 3 - Petr Beaupre, Earl Unger, Burton Jernigan, and Alice Ribbons
How to Train Your Dragon
- How to Train Your Dragon - Red Death
- Race to the Edge - (spoiler)
- How to Train Your Dragon 2 - Drago Bludvist
- How to Train Your Dragon: The Hidden World - Grimmel the Grisly
Hudson Hawk
- Darwin Mayflower
- Minverva Mayflower
The Hunchback of Notre Dame
- Judge Claude Frollo
Hunter Killer
- Dmitri Durov
Hyrule Warriors
- Cia
- Ganondorf (final)
Ice Age
- Ice Age - Soto
- Ice Age 2: The Meltdown - Cretaceous and Maelstrom
- Ice Age 3: Dawn of the Dinosaurs - Rudy
- Ice Age: Continental Drift - Captain Gutt
Ice Climber
- Condor
Ikki Tousen
- Ikki Tousen - Chuuei Toutaku
- Ikki Tousen: Dragon Destiny - Dragon Sousou
The Incredibles
- The Incredibles - Syndrome
- The Incredibles 2 - (unconfirmed, but probably Evelyn Deavor)
Independence Day
- Harvester Queen
Indiana Jones
- Raiders of the Lost Ark - Rene Belloq
- Temple of Doom - Mola Ram
- The Last Crusade - Walter Donovan
- Kingdom of the Crystal Skull - Irina Spalko
Inkheart
- Capricorn
Inspector Gadget
- Sanford Scolex
In the Line of Fire
- Mitch Leary
Inuyasha
- Main series - Naraku, Shikon Jewel (final)
- Affections Touching Across Time - Menomaru
- The Castle Beyond the Looking Glass - Princess Kaguya
- Swords of an Honorable Ruler - Sounga
- Fire on the Mystic Island - Ryura
I Spy
- Arnold Gundars, (spoiler)
It
- Pennywise/It
Ivanhoe
- Bois-Guilbert
- Prince John (Bigger Bad)
Jack and the Beanstalk (Abbott and Costello)
- Giant
Jack the Giant Killer
- Pendragon
Jackie Chan Adventures
- Season 1 - Shendu
- Season 2 - Shendu, Daolon Wong
- Season 3 - Daolon Wong, I think
- Season 4 - Tarakudo
- Season 5 - Drago
Jack Reacher
- Jack Reacher - The Zec
- Jack Reacher: Never Go Back - General Harkness
Jack the Giant Killer
- Pendragon
James and the Giant Peach
- Aunt Sponge
- Aunt Spiker
James Bond
- Dr. No - Dr. No, Ernst Stavro Blofeld (Bigger Bad)
- From Russia with love - Rosa Klebb, Ernst Stavro Blofeld (Bigger Bad)
- Goldfinger - Auric Goldfinger
- Thunderball - Emilio Largo, Ernst Stavro Blofeld (Bigger Bad)
- You Only Live Twice - Ernst Stavro Blofeld
- On Her Majesty's Secret Service - Ernst Stavro Blofeld
- Diamonds Are Forever - Ernst Stavro Blofeld
- Live and Let Die - Dr. Kananga
- The Man with the Golden Gun - Francisco Scaramanga
- The Spy Who Loved Me - Karl Stromberg
- Moonraker - Hugo Drax
- For Your Eyes Only - Aris Kristatos
- Octopussy - General Orlov, Kamal Khan
- A View to a Kill - Max Zorin
- The Living Daylights - Georgi Koskov, Brad Whitaker (Bigger Bad)
- Licence to Kill - Franz Sanchez
- GoldenEye - Alec Trevelyan
- Tomorrow Never Dies - Elliot Carver
- The World is Not Enough - Renard, Elektra King
- Die Another Day - Gustav Graves
James Bond (reboot)
- Casino Royale - Le Chiffre, Mr. White
- Quantum of Solace - Dominic Greene
- Skyfall - Raoul Silva
- Spectre - Ernst Stavro Blofeld
Jaws
- Jaws - Shark
- Jaws 2 - Shark (2)
- Jaws 3 - Shark (3)
John Carter
- Sab Than
- Matai Shang
John Wick
- Viggo Tarasov
Johnny Mnemonic
- Shinji
- Takahashi
JoJo's Bizarre Adventures
- Phantom Blood - Dio Brando
- Battle Tendency - Kars
- Stardust Crusaders - Dio Brando
- Diamond is Unbreakable - Yoshikage Kira
Journey to the Center of the Earth
- Count Saknussem
(Note: This is the original, the reboot has no main villains) Jumanji
- Russel Van Pelt
The Jungle Book
- Shere Khan
Jupiter Ascending
- Balem
Jurassic Park
- Jurassic Park - Dennis Nedry, Lewis Dodgson (Bigger Bad), Velociraptors
- Jurassic Park: The Lost World - Peter Ludlow
- Jurassic World - Indominus Rex, Vic Hoskins (secondary)
The Karate Kid
- The Karate Kid - Johnny Lawrence, John Kreese (Bigger Bad)
- The Karate Kid II - Sato, Chozen
- The Karate Kid III - John Kreese, Terry Silver
Key Largo
- Johnny Rocco
Kid Icarus
- Kid Icarus - Medusa
- Kid Icarus: Of Myths and Monsters - Orcos
- Kid Icarus: Uprising - Hades
Kill Bill
- Bill
Kindergarten Cop
- Cullen Crisp
King Arthur
- Cerdic
Kingsman
- The Secret Service - Richmond Valentine
- The Golden Circle - Poppy Adams
Kirby
- Kirby's Dream Land - King Dedede
- Kirby's Adventure - Nightmare
- Kirby's Dream Land 2 - Dark Matter
- Kirby's Dream Land 3 - Zero
- Kirby 64: The Crystal Shards - 02
- Kirby & the Amazing Mirror - Dark Mind
- Kirby: Canvas Curse - Drawcia
- Kirby: Squeak Squad - Daroach, Dark Nebula (final)
- Kirby's Epic Yarn - Yin-Yarn
- Kirby: Mass Attack - Necrodeus
- Kirby's Return to Dream Land - Magolor, Master Crown
- Kirby: Triple Deluxe - Queen Sectonia
- Kirby and the Rainbow Curse - Dark Crafter
- Kirby: Planet Robobot - President Haltmann, Star Dream (final)
- Kirby Star Allies - Void Termina
Kirby: Right Back at Ya
- King Dedede
- NME
Kong
- Ramone De La Porta
- Chiros
- King of Atlantis - Queen Reptilla
Krull
- The Beast
Kung Fu Hustle
- Brother Sum
Kung Fu Panda
- Kung Fu Panda - Tai Lung
- Kung Fu Panda 2 - Shen
- Kung Fu Panda 3 - Kai
Ladyhawke
- Bishop of Aquila
Lake Placid
- Crocodile
The Land Before Time
- The Land Before Time - Sharptooth
- The Land Before Time II: The Great Valley Adventure - Ozzy and Strut
- The Land Before Time III: The Time of the Great Giving - Hyp
- The Land Before Time IV: Journey Through the Mists - Ichy and Dill
- The Land Before Time V: The Mysterious Island - Striped Sharptooth
- The Land Before Time VI: The Secret of Saurus Rock - Allosaurus
- The Land Before Time VII: The Stone of Cold Fire - Pterano (at first), Rinkus and Sierra\
- I haven't kept track past here
Lara Croft: Tomb Raider
- Lara Croft: Tomb Raider - Manfred Powell
- Lara Croft: Tomb Raider: Cradle of Life - Jonathan Reiss
Laserblast
- Billy Duncan (corrupted by the alien laser)
The Last Boy Scout
- Sheldon Marcone
The Last Kingdom
- Season 1 - Guthrum
- Season 2 - Kjartan (Part 1), Sigefrid (Part 2)
- Season 3 - Aethelwold, Cnut
The Last Starfighter
- Xur
The Last Unicorn
- King Haggard
The Lazer Collection
- Dr. Octogonapus, Cell (Bigger Bad)
Legend
- Lord of Darkness
The Legend of Spyro
- A New Beginning - Cynder
- The Eternal Night - Gaul
- Dawn of the Dragon - Malefor
Leprechaun
- Leprechaun (note: I think it's a different leprechaun each time)
Lethal Weapon
- Lethal Weapon - General Peter McAllister
- Lethal Weapon 2 - Arjen Rudd
- Lethal Weapon 3 - Jack Travis
- Lethal Weapon 3 - Wah Sing Ku
The Librarians
- Season 1 - Lancelot Dulaque
- Season 2 - Prospero
- Season 3 - Apep
- Season 4 - Nicole
The Life & Adventures of Santa Claus
- King Mogorb
The Lion King
- The Lion King - Scar
- The Lion King II: Simba's Pride - Zira
The Lion, the Witch, and the Wardrobe (animated)
- The White Witch
The Little Mermaid
- Ursula
Little Nemo: Adventures in Slumberland
- Nightmare King
Logan's Run
- Computer
Lord of the Rings
- The Hobbit - Smaug, Azog, Sauron
- Lord of the Rings - Sauron
The Loves of Hercules
- Licos
Lucifer
- Season 1 - Amenadiel, Malcolm Graham
- Season 2 - Goddess
- Season 3 - (spoiler)
- Season 4 - Father Kinley
Lucky Number Slevin
- The Boss
- The Rabbi
Macbeth
- Macbeth
MacGruber
- Dieter Von Cunth
The Magnificent Seven
- Bartholomew Bogue
Maleficent
- King Stefan
Mario
- Series - Bowser
- Donkey Kong - Donkey Kong
- Donkey Kong Jr. - Mario
- Donkey Kong 3 - Donkey Kong
- Super Mario Bros. 2 - Wart
- Super Mario Land - Tatanga
- Super Mario Land 2: 6 Golden Coins - Wario
- Luigi's Mansion - King Boo
- Luigi's Mansion 2: Dark Moon - King Boo
- Super Mario Sunshine - Bowser Jr., Bowser (Bigger Bad)
- New Super Mario Bros. - Bowser Jr., Bowser (Bigger Bad)
- Mario & Luigi/RPG
- Super Mario RPG: Legend of the Seven Stars - Smithy
- Mario & Luigi: Superstar Saga - Cackletta
- Mario & Luigi: Partners in Time - Princess Shroob, (spoiler)
- Mario & Luigi: Bowser's Inside Story - Fawful, Dark Bowser (final)
- Mario & Luigi: Dream Team - Antasma, Bowser
- Mario & Luigi: Paper Jam - Bowser, Paper Bowser
- Paper Mario
- Paper Mario - Bowser
- Paper Mario: The Thousand-Year Door - Grodus, Shadow Queen (final)
- Super Paper Mario - Count Bleck, Dimentio (final)
- Paper Mario Sticker Star - Bowser
Marvel Cinematic Universe
- Captain America: The First Avenger - Red Skull
- Captain Marvel - (spoiler)
- Iron Man - Obadiah Stane
- The Incredible Hulk - General Ross, Emil Blonsky/Abomination
- Iron Man 2 - Ivan Vanko
- Thor - Loki
- The Avengers - Loki, Thanos (Bigger Bad)
- Iron Man 3 - (spoiler)
- Thor: The Dark World - Malekith
- Captain America: The Winter Soldier - (spoiler)
- Guardians of the Galaxy - Ronan the Accuser
- Guardians of the Galaxy Vol. 2 - (spoiler)
- Avengers: Age of Ultron - Ultron
- Ant-Man - Darren Cross
- Captain America: Civil War - Helmut Zemo
- Black Panther - Killmonger
- Spiderman: Homecoming - Adrian Toomes/The Vulture
- Doctor Strange - Kaecilius
- Thor Ragnarok - Hela
- Ant-Man and the Wasp - Ghost
- Avengers: Infinity War - Thanos
- Avengers: Endgame - Thanos
The Mask
- Dorian Tyrell
The Mask of Zorro
- Don Rafael Montero
The Master of Disguise
- Devlin Bowman
Matilda
- Agatha Trunchbull
The Matrix
- Agent Smith
Max Keeble's Big Move
- Principal Jindraike
Max Steel (film)
- Miles Edwards
Maze Runner
- Ava Paige
The Mechanic
- Dean Sanderson (The Mechanic)
- Riah Crain (Mechanic: Resurrection)
Mega Man
- Main series - Dr. Wily
- X series - Sigma
Megamind
- Tighten
Men in Black
- Men in Black - Edgar the Bug
- Men in Black II - Serleena
- Men in Black 3 - Boris the Animal
- Men in Black International - The Hive
The Mentalist
- Red John
Metal Gear:
- Metal Gear Solid 3: Snake Eater - Colonel Volgin
- Metal Gear Solid: Peace Walker - Paz Ortega Andrade
- Metal Gear Solid V: Ground Zeroes - Skull Face
- Metal Gear Solid V: The Phantom Pain - Skull Face
- Metal Gear - Big Boss
- Metal Gear 2: Solid Snake - Big Boss
- Metal Gear Solid - Liquid Snake
- Metal Gear Solid 2: Sons of Liberty - Solidus Snake
- Metal Gear Solid 4: Guns of the Patriots - Liquid Ocelot
Metroid
- Metroid Prime - Metroid Prime
- Metroid Prime 2: Echoes - Emperor Ing
- Metroid Prime 3: Corruption - Dark Samus
Mighty Joe Young
- Andrei Strasser
Midnight Run
- Jimmy Serrano
Mission Impossible
- Mission Impossible - (spoiler)
- Mission Impossible 2 - Sean Ambrose
- Mission Impossible 3 - Owen Davian
- Mission Impossible: Ghost Protocol - Kurt Hendricks
- Mission Impossible: Rogue Nation - Solomon Lane
- Mission Impossible: Fallout - Solomon Lane, (spoiler)
Miss Peregrine's Home for Peculiar Children
- Mr. Barron
Moana
- Te Ka
Monster Rancher
- Series - Moo
- Season 3 - Evil General Durahan
Monsters Inc
- Randall Boggs
Monsters vs. Aliens
- Gallaxhar
MonsterVerse
- Kong: Skull Island - Preston Packard, Ramarak
- Godzilla - Male MUTO, Female MUTO
Mortal Engines
- Thaddeus Valentine
The Mosquito Coast
- Allie Fox
Mother
- Mother - Gigyas
- Earthbound - Gigyas
- Mother 3 - Porky
Mr. Deeds
- Chuck Cedar
Mr. Right
- Von Cartigan, Ed Hopper
Mulan
- Shan Yu
The Mummy
- Imhotep
The Mummy (2017)
- Princess Ahmanet
My Favorite Martian
- Dr. Elliot Coleye
My Little Pony (G1)
- Rescue at Midnight Castle - Tirek
- Escape from Catrina - Catrina
- My Little Pony: The Movie - Hydia
- The End of Flutter Valley - Hydia
- The Ghost of Paradise Estate - Squirk
- The Great Rainbow Caper - Gonk and Glouda
- The Glass Princess - Princess Porcina, Raptorians (final)
- Bright Light - Arabus
- The Return of Tambelon - Grogar
- Fugitive Flowers - The Flores
- Baby, It's Cold Outside - King Charlatan
- Crunch the Rockdog - Crunch
- The Revolt of Paradise Estate - Beezen
- The Quest of the Princess Ponies - Lavan
- Somnambula - Somnambula
- The Prince and the Pony - The Duchess
My Little Pony: Friendship is Magic
- Friendship is Magic - Nightmare Moon
- The Return of Harmony - Discord
- A Canterlot Wedding - Queen Chrysalis
- The Crystal Empire - King Sombra
- Twilight's Kingdom - Lord Tirek
- The Cutie Map - Starlight Glimmer
- The Cutie Remark - Starlight Glimmer
- To Where and Back Again - Queen Chrysalis
- Shadow Play - The Pony of Shadows
- My Little Pony: The Movie - The Storm King
- School Daze - Chancellor Neighsay
- School Raze - Cozy Glow
- The Beginning of the End - King Sombra
- The Ending of the End - Queen Chrysalis, Lord Tirek, Cozy Glow
Equestria Girls (spinoff of MLP)
- Equestria Girls - Sunset Shimmer
- Rainbow Rocks - Adagio Dazzle, Sonata Dusk Aria Blaze
- Friendship Games - Principal Cinch, Midnight Sparkle
- Legend of Everfree - (spoiler)
- Forgotten Friendship - (spoiler)
- Spring Breakdown - EG Rainbow Dash
Mystery Men
- Casanova Frankenstein
Mystery Science Theater 3000
- Seasons 1-7 - Dr. Clayton Forrester
- Seasons 8-10 - Pearl Forrester
- Seasons 11-12 - Kinga Forrester
Napoleon Dynamite
- Uncle Rico
The Chronicles of Narnia (BBC)
- The Lion, the Witch, and the Wardrobe - The White Witch
- Prince Caspian - King Miraz
- The Silver Chair - The Green Lady
The Chronicles of Narnia (Disney)
- The Lion, the Witch, and the Wardrobe - The White Witch
- Prince Caspian - King Miraz, Sopespian (final)
- The Voyage of the Dawn Treader - Dark Mist
Naruto
- Part I - Orochimaru
- Part II - Tobi, Madara Uchiha
- Final - Kaguya Otsutsuki
National Treasure
- National Treasure - Ian Howe
- National Treasure 2: Book of Secrets - Mitch Wilkinson
Next
- Mr. Smith (though he seems to take orders from an unnamed Bigger Bad)
The Neverending Story
- The Neverending Story - The Nothing
- The Neverending Story II: The Next Chapter - Xayide
- The Neverending Story III: Escape from Fantasia - Slip
The Nightmare Before Christmas
- Oogie Boogie
No Way Out
- Scott Pritchard (even though Brice was the higher-ranking one and the actual killer, Pritchard was the mastermind of the plan to frame Farrell and sending assassins)
Oblivion
- Sally
Oliver & Company
- Bill Sykes
Once Upon A Time
- Season 1 - Regina
- Season 2 Part 1 - Cora
- Season 2 Part 2 - Greg Mendell, Tamara
- Season 3 Part 1 - Peter Pan
- Season 3 Part 2 - Zelena
- Season 4 Part 1 - Ingrid
- Season 4 Part 2 - Mr. Gold
- Season 5 Part 1 - King Arthur (some might also count Emma Swan and Nimue)
- Season 5 Part 2 - Hades
- Season 6 Part 1 - The Evil Queen
- Season 6 Part 2 - The Black Fairy
Osmosis Jones
- Thrax
The Outlaw Josey Wales
- Senator Lane (some might say Terrill, who has more of a presence)
The Pagemaster
- Mr. Hyde
- Long John Silver
- Dragon
Percy Jackson & the Olympians
- Luke
Perfect Dark
- Skedar King
Phantom of the Paradise
- Swan
Pikmin
- Pikmin - Emperor Bulbax
- Pikmin 2 - Titan Dweevil
Pinocchio
- Pinocchio - Honest John
- Pinocchio and the Emperor of the Night - The Emperor of the Night
Pirates of the Caribbean
- Curse of the Black Pearl - Captain Barbossa
- Dead Man's Chest - Davy Jones
- At World's End - Cutler Beckett
- On Stranger Tides - Blackbeard
Planet of the Apes (reboot trilogy)
- Rise of the Planet of the Apes - Steven Jacobs
- Dawn of the Planet of the Apes - Koba
- War for the Planet of the Apes - Colonel McCullough
Pokemon
- Series - Giovanni
- Mewtwo Strikes Back - Mewtwo
- The Power of One - Lawrence III
- Spell of the Unown - Unown
- Mewtwo Returns - Giovanni
- Celebi: Voice of the Forest - Iron Masked Marauder
- Latios and Latias - Annie and Oakley
- The Mastermind of Mirage Pokemon - (spoiler)
- Diamond and Pearl - Cyrus
- XY & Z - Lysandre
- Note: I really lost interest past the first generation, aside from checking out the spectacular finale of Diamond and Pearl
Power Rangers
- Power Rangers: The Movie - Ivan Ooze
- Turbo: A Power Rangers Movie - Divatox, Maligore (final)
Predator
- Predator - Predator
- Predator 2 - Predator (2)
- Alien vs. Predator - Xenomorph Queen
- Alien vs. Predator: Requiem - Predalien
- Predators - Berserker Predator
The Prince of Egypt
- Rameses
Prince of Persia: Sands of Time
- Nizam
Prince Valiant
- Sir Brack
The Princess and the Frog
- Dr. Facilier
The Princess Bride
- Prince Humperdinck
Princess Gwenevere and the Jewel Riders
- Season 1 - Lady Kale
- Season 2 - Morgana
The Princess Twins of Legendale
- Queen Dume
Prison Break
- General Krantz
Push
- Henry Carver
Quest for Camelot
- Ruber
The Quick and the Dead
- John Herod
Quigley Down Under
- Elliott Marston
Rambo
- First Blood - Will Teasle
- Rambo: First Blood Part II - Lt. Col. Podovsky
- Rambo III - Colonel Zaysen
- Rambo - Major Tint
Rampage
- Claire Wyden
Rat Race
- Duane Cody
- Blaine Cody
- Harold Grisham (final)
Ready Player One
- Nolan Sorrento
Recess: School's Out
- Philium Benedict
Red
- Red - (spoiler)
- Red 2 - Jack Horton, (spoiler)
Red vs. Blue
- O'Malley
Redwall
- Redwall the Movie - Cluny the Scourge
- Mattimeo: A Tale of Redwall - Slagar the Slaver, Ironbeak
The Rescuers
- The Rescuers - Madame Medusa
- The Rescuers Down Under - Percival C. McLeach
Riddick
- The Chronicles of Riddick - Lord Marshal
- Riddick - Santana
Rise of the Planet of the Apes
- Rise of the Planet of the Apes - Jacob Stevens
- Dawn of the Planet of the Apes - Koba
The Road to El Dorado
- Tzekel-Kan
Robin Hood (animated)
- Prince John
Robin Hood: Prince of Thieves
- Sheriff of Nottingham
RoboCop
- Clarence Boddicker
- Dick Jones
Robots
- Ratchet
- Madam Gasket
The Robot vs. the Aztec Mummy
- Dr. Krupp
The Rock
- Frank Hummel (debatable, as he is implied to only be bluffing with his threats and had a noble cause)
- Captain Frye, Captain Darrow
The Rocky Horror Picture Show
- Frank-N-Furter
Rogue Spear
- Samed Vezirzade
- Maxim Kutkin
Romeo and Juliet
- Tybalt Capulet
Rubber
- Robert the tire
The Rundown
- Cornelius Bernard Hatcher
Rush Hour
- Rush Hour - Thomas Griffin/Juntao
- Rush Hour 2 - Ricky Tan
- Rush Hour 3 - Kenji
Ruthless People
- Sam Stone
The Sacketts
- Ira Bigelow
Safety Patrol
- Bert Miller
- Mrs. Day
Sahara
- General Kazim
Sailor Moon
- Sailor Moon - Queen Beryl, the Negaforce (Bigger Bad)
- Sailor Moon R - Prince Diamond, Wiseman (final)
- The Promise of the Rose - Kisenian Blossom
- Sailor Moon S - Germatoid (possessing Doctor Tomoe), Mistress 9 (Bigger Bad), Pharaoh 90 (Biggest Bad)
- Hearts in Ice - Princess Snow Kaguya
- Sailor Moon Super S - Zirconia, Queen Nehelenia (Bigger Bad)
Sailor Moon Crystal
- Season 1 - Queen Beryl, Queen Metalia (Bigger Bad)
- Season 2 - Prince Demande, Wiseman (final)
- Season 3 - Pharaoh 90
Salt
- Orlov
Saw
- Saw, Saw II, and Saw III - Jigsaw
- Saw IV, Saw V, Saw VI, and Saw 3D - Mark Hoffman
Scanners
- Darryl Revok
Scary Movie
- Scary Movie - (spoiler)
- Scary Movie 2 - Hugh Kane
- Scary Movie 3 - Tabitha
- Scary Movie 4 - Jigsaw
Seventh Son
- Mother Malkin
The Shannara Chronicles
- Season 1 - Dagda Mor
- Season 2 - General Riga, Warlock Lord
She-Ra and the Princesses of Power
- Hordak
Sherlock
- Jim Moriarty
Sherlock Holmes
- Sherlock Holmes - Geoffrey Blackwood
- Sherlock Holmes: Game of Shadows - Professor James Moriarty
Shrek
- Puss in Boots - (spoiler), Jack and Jill
- Shrek - Lord Farquaad
- Shrek 2 - Fairy Godmother
- Shrek the Third - Prince Charming
- Shrek Forever After - Rumpelstiltskin
Silverado
- Ethan McKendrick
Sin City
- Roark Jr.
- Senator Roark
- Cardinal Roark
- Kevin
- Manute
- Ava
Skyscraper
- Kores Botha
Sleeping Beauty
- Maleficent
Snakes on a Plane
- Eddie Kim
The Snow Queen
- The Snow Queen
The Snow Queen (older)
- The Snow Queen
Snow White and the Seven Dwarfs
- Evil Queen
Sonic
- Series - Dr. Eggman
- Tails Adventure - Grand Battle Kukku 15th
- Sonic Adventure - Dr. Eggman, Chaos (final)
- Sonic Adventure 2 - Dr. Eggman, Shadow the Hedgehog
- Sonic Advance 3 - Dr. Eggman, Gemerl (final)
- Sonic Heroes - (spoiler)
- Shadow the Hedgehog - Black Doom
- Sonic Riders: Zero Gravity - SCR-HD/Master Core: ABIS
- Sonic Free Riders - Dr. Eggman, (spoiler)
- Sonic Rush - Dr. Eggman, Eggman Nega
- Sonic Rush Adventure - Captain Whisker, (spoiler)
- Sonic the Hedgehog (2006) - Dr. Eggman, Mephiles the Dark, Iblis
- Sonic Rivals - Eggman Nega
- Sonic Rivals 2 - Eggman Nega, the Ifrit (final)
- Sonic Unleashed - Dr. Eggman, Dark Gaia
- Sonic Generations - Time Eater, (spoiler)
- Sonic Lost World - Zavok, (spoiler)
Soul Eater
- Medusa
- Arachne
- Asura
Space Jam
- Mr. Swackhammer
Spaceballs
- President Skroob
Spacehunter: Adventures in the Forbidden Zone
- Overdog
Spartacus
- Blood and Sand - Quintus Lentulus Batiatus
- Vengeance - Gaius Claudius Glaber
- War of the Damned - Marcis Licinius Crassus
Speed
- Howard Payne
Spiderman
- Spiderman - The Green Goblin
- Spiderman 2 - Doctor Octopus
- Spiderman 3 - Venom
The Spiderwick Chronicles
- Mulgarath
Splash
- Dr. Ross
Splatoon
- DJ Octavio
Spy Kids
- Spy Kids - Floop (at first), Alexander Minion
- Spy Kids 2: The Island of Lost Dreams - Donnogan Giggles
- Spy Kids 3D: Game Over - The Toymaker
Spyro
- Spyro the Dragon - Gnasty Gnorc
- Spyro 2: Ripto's Rage - Ripto
- Spyro: Year of the Dragon - The Sorceress
Stan Helsing
- Fweddy
- Mason
- Michael Criers
- Needlehead
- Pleatherface
- Lucky
Starcrash
- Count Zarth Arn
Stardust
- Lamia
Star Fox
- Star Fox 64 - Andross
- Star Fox Adventures - General Scales, (spoiler)
- Star Fox Assault - Aparaoid Queen
Stargate
- Ra
Starship Troopers
- Behemecoatyl
Star Trek
- The Motion Picture - V'Ger
- The Wrath of Khan - Khan
- The Search for Spock - Commander Kruge
- The Voyage Home - Whale Probe
- The Final Frontier - "God"
- The Undiscovered Country - General Chang
- Generations - Soran
- First Contact - Borg Queen
- Insurrection - Ru'afo
- Nemesis - Shinzon
- Star Trek - Captain Nero
- Star Trek: Into Darkness - Khan (AU), Admiral Marcus
- Star Trek: Beyond - Krall
Star vs. the Forces of Evil
- Ludo, Toffee
Star Wars
- Main - Emperor Palpatine
- Solo - Dryden Vos, (spoiler)
The Sting
- Doyle Lonnegan
Strange Brew
- Brewmeister Smith
Street Fighter
- Street Fighter II - M. Bison
- Street Fighter III - Gill
- Street Fighter IV: M. Bison
- Street Fighter V - M. Bison
Street Sharks
- Dr. Paradigm
Strike Back
- Season 1 - Latif
- Season 2 - Conrad Knox
Stripes
- Captain Stillman
The Stupids
- Colonel Neidermeyer
Super Mario Bros. (film)
- King Koopa
Super Smash Bros. Brawl
- Tabuu
Super Smash Bros. Ultimate
- Galeem
- Dharkon
Superhero Movie
- The Hourglass
Superman
- Superman - Lex Luthor
- Superman II - General Zod
Supernatural
- Season 1 - Azazel
- Season 2 - Azazel
- Season 3 - Lilith
- Season 4 - Lilith
- Season 5 - Lucifer
- Season 6 - Crowley, Eve, Raphael
- Season 7 - Dick Roman
- Season 8 - Crowley
- Season 9 - Abaddon, Metatron
- Season 10 - Rowena
- Season 11 - Amara
- Season 12 - Lucifer, Doctor Hess
- Season 13 - Asmodeus, Alternate Michael
- Season 14 - Alternate Michael
- Season 15 - God
The Swan Princess
- The Swan Princess - Rothbart
- The Swan Princess Christmas - Rothbart
- The Swan Princess II: Escape from Castle Mountain - Clavius
- The Swan Princess: The Mystery of the Enchanted Treasure - Zelda
- The Swan Princess: A Royal Family Tale - The Forbidden Arts
Taken
- Taken - Marko
- Taken 2 - Murad
Tarzan
- Clayton
Teenage Mutant Ninja Turtles
- Teenage Mutant Ninja Turtles - Shredder
- Teenage Mutant Ninja Turtles II: The Secret of the Ooze - Shredder
- Teenage Mutant Ninja Turtles III - Lord Norinaga, Walker
Teen Titans
- Season 1 - Slade
- Season 2 - Slade
- Season 3 - Brother Blood
- Season 4 - Trigon
- Season 5 - Brain
The Terminator
- The Terminator - The Terminator
- Terminator 2: Judgment Day - T-1000
- Terminator 3: Rise of the Machines - TX
- Terminator Genisys - Skynet
The Texas Chainsaw Massacre
- Leatherface, Drayton Sawyer (Bigger Bad)
The Thief and the Cobbler
- ZigZag
- King One Eye
This Island Earth
- The Monitor
The Three Musketeers
- The Three Musketeers - Cardinal Richelieu
- The Four Musketeers - Milady de Winter
Timecop
- Senator McComb
Timeline
- Robert Doniger
- Lord Oliver
Titan AE
- Queen Drej
Tom and Jerry
- Christine Figg
Tomb Raider trilogy
- Tomb Raider Anniversary - Jacqueline Natla
- Tomb Raider Legend - James Rutland, Amanda Evert
- Tomb Raider Underworld - Amanda Evert, Jacqueline Natla
Tomb Raider (2013)
- Father Mathias
- Himiko (Bigger Bad)
Tomb Raider (2018)
- Mathias Vogel
Tonic Trouble
- Grögh the Hellish
Total Recall
- Vilos Cohaagen
Total Recall (remake)
- Vilos Cohaagen
The Towering Inferno
- Roger Simmons
Toy Story
- Toy Story - Sid Phillips
- Toy Story 2 - Stinky Pete
- Toy Story 3 - Lotso
Transformers
- Transformers - Megatron
- Transformers: Revenge of the Fallen - The Fallen
- Transformers: Dark of the Moon - Megatron
Transporter
- The Transporter - Mr. Kwai
- Transporter 2 - Gianni Chellini
- Transporter 3 - Jonas Johnson
Treasure Planet
- Scroop
Tron
- Master Control Program
True Lies
- Salim Abu Aziz
True Romance
- Blue Lou Boyle (unseen)
The Trumpet of the Swan
- Boyd
The Tuxedo
- Dietrich Banning
Twins
- Webster
Twitches
- Thantos
Uncharted
- Uncharted: Drake's Fortune - Gabriel Roman, Atoq Navarro (final)
- Uncharted 2: Among Thieves - Zoran Lazarevic
- Uncharted 3: Drake's Deception - Katherine Marlowe
Under Siege
- Under Siege - Bill Stranix
- Under Siege 2: Dark Territory - Travis Dane
The Untouchables
- Al Capone
Up
- Charles Muntz
Up, Up, and Away
- Malcolm
The Vampire's Assistant
- Desmond Tiny
Van Helsing
- Count Dracula
Venom
- Carlton Drake
- Riot
V for Vendetta
- Chancellor Adam Sutler
Virtuosity
- SID
Voltron: Legendary Defender
- Seasons 1 and 2 - Zarkon
- Season 3 - Lotor
- Season 4 - Zarkon
- Season 5 - Haggar
- Season 6 - (spoiler)
- Season 7 - Sendak
The Walking Dead
- Season 1 - Zombies
- Season 2 - Shane Walsh
- Season 3 - The Governor
- Season 4 - The Governor, Joe
- Season 5 - No "main" villain, though there are antagonists with arcs at 5 episodes tops
- Seasons 6-8 - Negan
- Season 9 - Alpha
The Warriors
- Luther
Waterworld
- The Deacon
We're Back! A Dinosaur's Story
- Professor Screweyes
The Whole Nine Yards
- Sophie
- Janni Gogolak
Willow
- Queen Bavmorda
Willy Wonka and the Chocolate Factory
- Veruca Salt
- Grandpa Joe
Winx Club
- Season 1 - Icy, Darcy, and Stormy
- Season 2 - Lord Darkar
- Season 3 - Valtor
- Season 4 - Ogron, Anagan, Gantlos, and Duman
Winx Club (4Kids)
- Season 1 - Icy, Darcy, and Stormy
- Season 2 - Lord Darkar
- Season 3 - Baltor
Winx Club (Nickelodeon)
- Season 3 - Valtor
- Season 4 - Ogron, Anagan, Gantlos, and Duman
- Season 5 - Tritannus
- Season 6 - Selina, Acheron
- Season 7 - Kalshara
The Wizard of Oz
- Oz: The Great and Powerful - The Wicked Witch of the East
- The Wizard of Oz - The Wicked Witch of the West
- Return to Oz - The Nome King
- Legend of Oz: Dorothy's Return - The Jester
Wizards of the Lost Kingdom
- Shurka (Wizards of the Lost Kingdom)
- Zarz (Wizards of the Lost Kingdom II)
Wreck-It Ralph
- King Candy
Xenoblade Chronicles
- Xenoblade Chronicles - Zanza
- Xenoblade Chronicles 2 - Amalthus
X-Men
- X-Men: First Class - Sebastian Shaw
- X-Men - Magneto
- X2 - William Stryker
- X-Men: The Last Stand - Magneto
- The Wolverine - (spoiler)
- X-Men: Days of Future Past - Bolivar Trask
- X-Men: Apocalypse - Apocalypse
- Deadpool - Francis Freeman/Ajax
- Deadpool 2 - (spoiler)
- Logan - Zander Rice
xXx
- xXx - Yorgi
- xXx: State of the Union - George Deckert
- xXx: Return of Xander Cage - (spoiler)
Your Highness
- Leezar
Yu-Gi-Oh!
- Season 1 - Maximillion Pegasus
- Season 2 - Marik Ishtar
- Season 3 - Noah Kaiba, (spoiler), Yami Marik
- Pyramid of Light - Anubis
- Season 4 - Dartz, Great Leviathan (Bigger Bad)
- Season 5 - Zigfried von Schroeder, Yami Bakura, Zorc
Zelda
- Skyward Sword - Ghirahim, Demise (Bigger Bad)
- Minish Cap - Vaati
- Four Swords - Vaati
- Ocarina of Time - Ganondorf
- Majora's Mask - Majora
- The Wind Waker - Ganondorf
- Phantom Hourglass - Bellum
- Spirit Tracks - Chancellor Cole, Malladus
- Twilight Princess - Zant, (spoiler)
- Four Swords Adventure - Vaati, Ganondorf (Calamity Ganon?)
- Breath of the Wild - Calamity Ganon
Spoilers
24:
- Season 5 - Charles Logan (answers to Graem, not allied with Bierko)
Bomberman
- Bomberman 64 - Sirius (final)
Clue
- Wadsworth/Mr. Boddy
The DaVinci Code
- The DaVinci Code - Leigh Teabing
- Angels and Demons - Patrick McKenna
- Inferno - Sienna Brooks
Dead Zone
- Greg Stillson
Despicable Me
- Despicable Me 2 - El Macho
Digimon (Season 2)
- Myotismon
Dollhouse
- Boyd Langton
Elysium
- C.M. Kruger (final)
The Equalizer
- The Equalizer 2 - Dave York
Equestria Girls
- Legend of Everfree - Gloriosa Daisy
- Forgotten Friendship - Wallflower Blush
Ford Fairlane
- Julian Grendel
Friday the 13th
- Friday the 13th Part V: A New Beginning - Roy Burns
Frozen
- Frozen - Prince Hans
- Frozen 2 - King Runeard
Fullmetal Alchemist
- Dante
Game of Thrones
- Season 8 - Daenerys Targaryen (final)
I Spy
- Rachel Wright
The League of Extraordinary Gentlemen
- Professor James Moriarty
Lucifer
- Season 3 - Marcus Pierce/Cain
Marvel Cinematic Universe:
- Captain Marvel - Supreme Intelligence
- Iron Man 3 - Aldrich Killian
- Captain America: The Winter Soldier - Alexander Pierce
- Guardians of the Galaxy Vol. 2 - Ego
Minority Report
- Lamar Burgess
Mission Impossible
- Mission Impossible - Jim Phelps
- Mission Impossible: Fallout - August Walker
The Nutcracker and the Four Realms
- Sugar Plum Fairy
Pokemon
- The Mastermind of Mirage Pokemon - Dr. Yung
Rango
- The Mayor
Red
- Red - Alexander Dunning
- Red 2 - Edward Bailey (final)
Scary Movie
- Scary Movie - Doofy Gilmore
Scooby Doo
- Scooby Doo - Scraffy Doo
- Scooby Doo 2: Monsters Unleashed - Jonathan Jacobo
Scream
- Scream - Billy Loomis
- Scream 2 - Mrs. Loomis
- Scream 3 - Roman Bridger
Scream (TV)
- Season 1 - Piper Shaw
- Season 2 - Kieran Wilcox
Shrek
- Puss in Boots - Humpty Dumpty
Sonic
- Sonic Heroes - Metal Sonic
- Sonic Free Riders - Metal Sonic (final)
- Sonic Rush Adventure - Dr. Eggman (Bigger Bad), Eggman Nega (Bigger Bad)
- Sonic Generations - Dr. Eggman (Bigger Bad)
- Sonic Lost World - Dr. Eggman (final)
Star Fox
- Star Fox Adventures - Andross (final)
Star Wars
- Solo - Darth Maul
Valerian and the City of a Thousand Planets
- Captain Filitt
Voltron: Legendary Defender
- Season 6 - Lotor
Who Framed Roger Rabbit
- Judge Doom
X-Men
- The Wolverine - Ichiro Yashida
- Deadpool 2 - Russell Collins/Firefist
xXx
- xXx: Return of Xander Cage - Jane Marke
Yu-Gi-Oh
- Season 3 - Gozaburo Kaiba (Bigger Bad)
Zelda
- Twilight Princess - Ganondorf (Bigger Bad)