What kind of ridiculous backstory is that?! I exist because of humankind's constant pollution of the environment! I am Vaccine Man!
~ Vaccine Man's Introduction

Vaccine Man is a villain from One Punch Man. He is the very first villain Saitama faces in the series and is said to be a Dragon level threat. Formed from the pollutions on Earth, Vaccine Man is determined to extinguish humanity from existence.


Vaccine Man appears as a regular, yet muscular, humanoid figure. He has two antennas from his forehead and veins across his entire body.

In his enhanced form, he gains spikes all over his body, sharp, long teeth and claws. His size also increases to great heights.


Vaccine Man shows up causing mass destruction, leveling up an entire city with his powers. When he's about to kill a child, Saitama shows up and save the kid. Vaccine Man claims he was born from the desires of Mother Earth, and that humans are a disease which is killing the planet and must be eradicated. He gets enraged when Saitama tells he is a hero just for hobby, transforming into a more demonic form and attacking Saitama, who pulverizes him with a single punch.


  • His appearance bears a striking resemblance to the Dragon Ball Z character, Piccolo.
    • Ironically, his English voice actor, Christopher R. Sabat also provides the voice for both characters, who would later on voice the My Hero Academia hero, All Might.


           One Punch Man Logo.png Villains

Monster Association
Orochi | Psykos
Black Sperm | Elder Centipede | Evil Natural Water | Fuhrer Ugly | Homeless Emperor | Gouketsu | Gums | Nyan | Overgrown Rover
Notable Members
Gale Wind | Hellfire Flame | Phoenix Man
Bakuzan | Choze | Volten | Hamikichi | Benpatsu |

Dark Matter Thieves
Notable Members
Geryuganshoop | Groribas | Melzargard

House of Evolution
Dr. Genus | Genus' Clones
Notable Members
Armored Gorilla | Beast King | Carnage Kabuto | Ground Dragon | Mosquito Girl | Praying Mantis

Ninja Village
Ninja Village Leader
Notable Members
Gale Wind | Hellfire Flame | Speed-o'-Sound Sonic

Notable Members
Deep Sea King | Lord Great White

Paradise Group
Notable Members

Ancient King | Crablante | Garou | Kombu Infinity | Pluton | Sky King | Vaccine Man | God | Marugori

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