The following are works or franchises which have been deemed incapable of having a Pure Evil villain, either because they are purely comedic in nature, little more than shock or exploitation, lack a consistent continuity, have some combination of the above, or possess some other factors which make them not conducive to have a Pure Evil villain. Creating a Pure Evil Proposal for a character from one of these works is forbidden, and anyone who does so will have their proposal immediately deleted and be removed from the whitelist.
- 120 Days of Sodom
- A Clockwork Orange
- A Serbian Film
- American Dad
- Beavis and Butthead
- Dick Figures
- Drawn Together
- Family Guy
- Happy Tree Friends
- Human Centipede
- Jeff the Killer
- Looney Tunes
- Minecraft (excluding Story Mode)
- Pico's School
- Ren and Stimpy
- Rick and Morty
- Riverdale
- The Simpsons
- South Park
- Tom and Jerry
- Where the Dead Go to Die