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The Viruses are anthropomorphic embodiments of disease (albeit in a family-friendly manner) and the main antagonists of the Dr. Mario series as well as the spinoff Dr. Luigi. Like many Super Mario villains they are comical in appearance and nature but are theoretically very dangerous opponents since they and their ilk would presumably spread illness across the Nintendo universe if Mario (and later Luigi) didn't keep them at bay.

Biography

Due to Dr. Mario being a puzzle-based, simplistic game, the Viruses do not speak nor have much influence but they serve as enemies along the line of famous video-game enemies such as Space Invaders or (fittingly) the original Koopa Troopas, having little backstory but being set as enemies for the hero to defeat.

Much like real-world viruses, the only way to defeat these microscopic creatures was with advanced medicine, symbolized in-game by stacking colored pills ontop of one another to destroy the virus that has the same color as the pills around it.

Other Media

Mario & Luigi

Mario & Luigi: Superstar Saga

Viruses appear in the Woohoo University, attacking by chewing at Mario and Luigi's heads, which can be countered by hitting them with a hammer. When hit by either brother, the Virus changes to a different color (red turns to blue, blue turns to yellow, yellow turns to red). When all Viruses in-battle match the same color, they are instantly defeated. The red Virus is weak to thunder, the blue Virus is weak to fire, while the yellow Virus is healed by either element.

Mario & Luigi: Bowser's Inside Story

A small blue Virus appears after knocking out all body sections of a Toothy, where it spits one out holding a small spear to attack the player.

Mario & Luigi: Dream Team

Viruses appear during the Ultibed hunt, attacking in groups of sixteen. Like in Mario & Luigi: Superstar Saga, hitting them makes them change color. Turning three or more connecting Viruses to the same color defeats them.

Super Smash Bros.

The Viruses appear as trophies in Super Smash Bros. Melee and Super Smash Bros. for Wii U unlocked at random. In Super Smash Bros. Brawl, the three Viruses are separate stickers. The blue Virus boosts electrical attacks, the red Virus boosts fire attacks, and the yellow Virus increases the health recovered from eating food. In Super Smash Bros. Ultimate, the Viruses appear as an advanced support spirit that reduces damage from poison attacks. Their spirit battle is a timed battle against a blue, red, and yellow Kirby on the Battlefield form of the Mario Bros. stage.

Mario Kart

The blue Virus appears in all three Mario Kart Arcade GP games as two items. The Wheel Virus interferes with the targeted racer by turning their wheel. It disappears after a certain time but can be passed to another racer by bumping into them. The Dizziness Virus causes the targeted racer's vision to blur. Like the Wheel Virus, it can be passed to another racer by colliding with them.

Navigation

           TheMario.png Villains

Koopa Troop
Universal
Bowser | Baby Bowser | Count Koopula | Bowser Jr. | Captain Goomba | Koopalings: (Larry Koopa | Morton Koopa Jr. | Wendy O. Koopa | Iggy Koopa | Roy Koopa | Lemmy Koopa | Ludwig Von Koopa) | Kamek | King Boo | Boom Boom | Pom Pom | Reznor | Burt the Bashful | Salvo the Slime | Roger the Potted Ghost | Koopa Kids | Hoo | Blizzaurus | Army Hammer Bro
Super Mario 64
King Bob-omb | Whomp King | Goomba King
Galaxy armada
King Kaliente | Bugaboom | MegaBug | Peewee Piranha | Topmaniac | Bouldergeist | Dino Piranha | Major Burrows | Prince Pikante | Rollodillo | Glamdozer | Giga Lakitu | Petey Piranha | Gobblegut
Super Mario 3D World
Hisstocrat
Super Mario Odyssey
Mechawiggler | Broodals: (Topper | Harriet | Spewart | Rango) | Madame Broode | Ruined Dragon | Cookatiel | Torkdrift
Mini-Troops
Goombas | Boos | Koopa Troopas | Chain Chomps | Hammer Bros. | Shy Guys | Magikoopas | Lakitu | Toadies | Bob-ombs | Piranha Plants | Bloopers | Wigglers

8 Bit Club
Wart | Mouser | Tryclyde | Birdo | Shy Guys

Paperverse
Koopa Troop (Paperverse)
Paper Bowser | Paper Bowser Jr. | Paper Koopalings: (Larry Koopa | Morton Koopa Jr. | Wendy O. Koopa | Iggy Koopa | Roy Koopa | Lemmy Koopa | Ludwig von Koopa) | Paper Kamek | Kammy Koopa | Paper Petey Piranha | Goomba King | Red & Blue Goomba | Koopa Bros | Tutankoopa | Tubba Blubba | General Guy | Lava Piranha | Huff N. Puff | Crystal King
Mini-Troops
Goombas | Boos | Koopa Troopas | Chain Chomps | Hammer Bros. | Shy Guys | Magikoopas | Bob-ombs | Piranha Plants
The Thousand Year Door
Secret Society of X-Nauts: Sir Grodus | Lord Crump | Shadow Sirens | Doopliss | Shadow Queen
Other
Hooktail | Gloomtail
Super Paper Mario
Count Bleck's Minions: Count Bleck | Nastasia | O'Chunks | Mimi | Dimentio | Mr. L | Brobot
Other
King Croacus | Shadoo | Wracktail | Skellobits: Bonechill | Count Bleck's Father | Francis

Folded Soldiers
King Olly | Handaconda | Paper Macho Soldiers
Legion of Stationery: Colored Pencils | Rubber Band | Hole Punch | Tape | Scissors | Stapler
Other: Lamp Scam Snifit

Smithy Gang
Smithy | Exor | Mack | Bowyer | Yaridovich | Axem Rangers | Blade | Count Down | Domino

Mario & Luigi
Elite Trio
Beanbean Kingdom
Popple | Rookie | Beanies | Mechawful | Sharpea | Troopea | Beanerang Bro | Clumphs | Lakipea

Cackletta and Fawful's faction
Cackletta | Fawful & Dark Star (Midbus, Fawful Express, Fawful Mountain, Super Peach's Castle of Fury, Crawful, Snawful, Chain Chawful, Fawflant, Fawful Guy, Fawfulcopter, Fawflopper, Mawful Mole, Mechawful)
Shroobs
Elder Princess Shroob | Princess Shroob | Sunnycide

Other
Antasma | Belome | Best Fitness Friends | Big Guy the Stilted | Black Jewel | Booster | Chuckolator | Cortez | Count Cannoli | Croco | Culex | Dodo | Donkey Kong | Donkey Kong (Mario VS Donkey Kong) | Draggadon | Foreman Spike | Gooper Blooper | Grouchy Possessor | Grubba | Harsh Possessor | Jojora | Jr. Troopa | Kaptain Skurvy | Kent C. Koopa | King K. Rool | Kritters | Lena | Lucien | Metal Mario | Mario | Mizzter Blizzard | Mollusque-Lancuer | Nabbit | Overset Possessor | Peps | Phantamanta | Portrait Ghosts: (Neville | Chauncey | Bogmire | Biff Atlas | Boolossus | Sir Weston | Vincent Van Gore) | President Koopa | Rabbids: (Phantom of the Bwahpera | Rabbid Kong) | Rawk Hawk | Ricky | Rudy the Clown | Sabasa | Shake King | Shrewd Possessor | Smorg | Squizzard | Tatanga | Three Little Pigheads | Tolstar | Tough Possessor | Tower Power Pokey | Valentina | Viruses | Waluigi | Wario | Watinga | Wingo | Yellow Belly/Helio

Comics
Bowser

Cartoon
Big Bad Wolf | "Crime Wave" Clyde | King Koopa | Robot Princess | Wizardheimer

See Also
Donkey Kong Villains | Luigi's Mansion Villains | Wario Villains

            Bro.png Villains

Subspace Army
Ancient Minister | Bowser | Bullet Bills | Duon | False Bowser | False Diddy Kong | False Peach | False Samus | False Zelda | Galleom | Ganondorf | Goombas | Hammer Bros. | King Statue | Koopa Troopas | Master Hand | Petey Piranha | Primids | Rayquaza | Ridley | Porky Minch | Shadow Bugs | Tabuu | Wario

World of Light
Crazy Hand | Dharkon | Dracula | Galeem | Galleom | Ganon | Giga Bowser | Master Hand | Marx

Playable Characters
Bowser | Bowser Jr. | Dark Pit | Dark Samus | Donkey Kong | Enderman | Ganondorf | Incineroar | Kazuya Mishima | King Dedede | King K. Rool | Koopalings (Larry, Roy, Wendy, Iggy, Morton, Lemmy, Ludwig) | Mario | Meta Knight | Mewtwo | Piranha Plant | Ridley | ROB | Sephiroth | Wario | Wolf O'Donnell | Zombie

Bosses
Crazy Hand | Dark Emperor | Dharkon | Dracula | Duon | Galeem | Galleom | Ganon | Giga Bowser | Marx | Master Hand | Master Core | Metal Face | Metal Mario | Petey Piranha | Porky Minch | Rathalos | Rayquaza | Ridley | Tabuu | Yellow Devil

Assists Trophies/Poké Ball Pokémon
Andross | Arceus | Black Knight | Burrowing Snagret | Chain Chomps | Chef Kawasaki | Darkrai | Deoxys | Devil | Dr. Wily | Entei | Elec Man | Ghirahim | Giratina | Ghosts | Gray Fox | Hammer Bros. | Klaptrap | Knuckle Joes | Kyurem | Lakitu | Lord Nightmare | Metroid | Meowth | Mimikyu | Mother Brain | Palkia | Phosphora | Shadow the Hedgehog | Skull Kid | Spinies | Starman | Unown | Waluigi

Trophies/Spirits/Stickers
Acro | Affinity | Air Man | Akuma | Alraune | Albert Wesker | Amalthus | Andrew Oikonny | Antasma | Aparoids | Aparoid Queen | Arlon | Ashnard | Axel | Baba | Baby Bowser | Babylon Rogues (Jet the Hawk, Wave the Swallow, Storm the Albatross) | Balrog | Banzai Bills | Bass | Big Boss | Bio Rex | Birdo | Black Shadow | Blood Falcon | Bokoblins | Blippers | Bloopers | Bombers | Bomb Man | Bonkers | Boos | Boom Boom | Boom Stompers | Box Boxer | Boxy | Broom Hatters | Bugzzy | Bumpety Bombs | Bulborbs | Burt the Bashful | Byrne | Cackletta | Calamity Ganon | Camus | Cappys | Captain Syrup | Carmilla | Chandelure | Chaos | Chaos Kin | Chargin' Chucks | Claus | Clubberskulls | Colonel Pluck | Condor | Cragalanche | Crash Man | Creepers | Count Bleck | Count Cannoli | Cranky Kong/Donkey Kong (Arcade) | Cut Man | Daphnes | Dark Man 4 | Dark Matter | Dark Mind | Darknuts | Daroach | Deadly Six (Zavok, Master Zik, Zeena, Zomom, Zazz, Zor) | Death | Deathborn | Devil Jin | Demise | Demon King Arzodius | Diggernaut | Dimentio | Dive Man | DJ Octavio | Don Bongo | Donkey Kong Jr. | Dragaux | Dr. Ivo "Eggman" Robotnik | Drill Man | Dry Bones | Eagle | E-123 Omega | Edelgard | Eggplant Wizard | EggRobos | Emerl | E.M.M.I. | Ender Dragon | Erazor Djinn | Father Balder | Fawful | Fiery Blowhog | Fire Man | Flages | Flash Man | Fortitudo | FU | Fynalle | Gangrel | Galacta Knight | Galactic Fiend Kraken | Galaxy Man | Guardians | Garon | Gengar | General Guy | Geese Howard | Gharnef | Ghasts | Ghosts | Gleeok | Goda | Gold Bone | Golems (Kirby) | Golems (Dragon Quest) | Gomorrah | Gooper Blooper | Gordos | Goro Akechi | Gravity Man | Great Reaper | Grief | Gruntilda | Guts Man | Hades | Hard Man | Hawke | Heihachi Mishima | Helmaroc King | Hewdraw | Hooktail | Hoopa Unbound | Hot Heads | Ice Man | Igor | Infinite | Ing | Inspired | Iori Yagami | Iridescent Glint Beetle | Iron Golems | Jade Face | Jeanne | Jin | Jin Kazama | Julius | Juri Han | Kalypso | Kamek | Kammy Koopa | Kanden | Karate Kong | Kass | King Bob-omb | King Boo | King Dice | King Dodongo | King Hippo | King Knight | King Olly | Kip | Kludge | Knight Man | Kracko | Kraid | Kritters | Kuma II | Kyle Merkulov | Leon Powalski | Lethiniums | Liquid Snake | Loptr | Lord Fredrik | Lurchthorns | Lyon | MB | M. Bison | Magnamalo | Magolor | Mahvas | Majora | Malladus | Malos | Master Belch | Master Kohga | Mecha Ridley | Medeus | Medusa | Megontas | Meta-Knights (Axe Knight, Javelin Knight, Mace Knight, Trident Knight, Blade Knight) | Metal Man | Metal Sonic | Metroid Prime | Mimicuties | Moblins | Mockiwis | Moley | Monoeyes | Mouser | Mr. Frosty | Mr. L | Mr. Sandman | Mr. Shine and Mr. Bright | Mugly | Nabbit | Napalm Man | Natah | Necrozma | Nihilego | Nightmare | Nina Williams | Ninja Kong | Noxus | Nruffs | Nutskis | O'Chunks | Octoman | Octoroks | Olaf | Ornes | Pandora | Panther Caroso | Paper Bowser | Parasite Queen | Paz Ortega Andrade | Peckish Aristocrabs | Phantom Ganon | Pico | Piglins | Pigma Dengar | Pigmasks | Plague Knight | Plasma Wisps | Plasm Wraith | Pom Pom | Pompy | Poppy Bros Jrs. | Princess Shroob | Quaggled Mireclops | Queen Metroid | Queen Sectonia | Quick Man | Rabbid Kong | Rabbids | Raphael the Raven | Reapers | Redd | Rhea | Revolver Ocelot | Riku | Risky Boots | Rockys | Rodin, the Infinite One | Roger the Potted Ghost | Rouge the Bat | Roxas | Rufus Shinra | Ryuichi and Ryuji | Sagat | Scarfies | Scurvy Crew | Shadow Beasts | Shadow Man | Shadow Queen | Shaft | Shake King | Sheegoth | Shield Knight | Shotzos | Shroobs | Shy Guys | Sidesteppers | Sigma | Sir Kibbles | Skeletons | Skull Man | Skuttlers | Slash Man | Slimes (Dragon Quest) | Slimes (Minecraft) | Smoky Prog | Snake Man | Snowmads | Solidus Snake | Space Pirates (Kid Icarus) | Space Pirates (Metroid) | Spark Man | Specknoses | Specter Knight | Spire | Squeakers | Starmans | Stu | Sword Man | Swooping Snitchbug | Sylux | Tacs | Tatanga | Thanatos | The Devil | The Skull | Therion | The Three Mage-Sisters (Francisca, Flamberge, Zan Partizanne) | Tiki Tak Tribe (Kalimba | Gong-Oh | Maraca Gang | Wacky Pipes | Cordian | Banjo Bottom | Xylobone) | Tiki Tong | Top Man | Trace | Travis Touchdown | Turks (Elena, Reno, Rude, Tseng) | Turret Tusk | Twinbellows | Twinrova | Ultimate Chimera | Vaati | Validar | Vega | Viridi | Viruses | Vivian | Vorash | Waddle Dees | Waddle Doos | Walhart | Walkys | Wart | Weavel | Wheelies | Whispy Woods | Whomps | Wigglers | Wind Man | Wollywog | Wood Man | Xord | X-Parasites | Yaldabaoth | Yuga | Yveltal | Zangief | Zant | Zero | Zingers | Zoda | Zurees

Others
Ansem | Billy Kane | Chang Koehan | Choi Bounge | Dr. Coyle | Dragonborn | Master Xehanort | Ryuji Yamazaki | Saïx | Solon | Spiders | Springtron | Team Rocket Grunts | Vanitas | Xemnas | Yiga Foot Soldiers

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