The Wirepullers of Smart Brain are the secret leaders of Smart Brain and overarching antagonists of the movie Kamen Rider 555: Paradise Lost. They are a trio of mysterious figures who are the superiors of Kyoji Murakami, the president of Smart Brain, and appear blurry faces on computer screens.
They are played by Gorō Naya, Seizō Katō and Shōzō Iizuka, all three of whom are voice actors who are notable for playing prominent villains in Kamen Rider and Super Sentai.
They met with Kyoji Murakami to discuss the Emperor's Belts, which they noted were extremely powerful. However, while a user for the first Belt, the Psyga Belt, had already been chosen in Leo, the Wirepullers asked Murakami who he intended to give the second belt to. Murakami replied by assuring the three Wirepullers that he already had someone in mind.
After both Kamen Rider Psyga and Kamen Rider Orga had been destroyed by Faiz, the Wirepullers ordered Smart Lady to execute Murakami for his failure.
- Curiously, the voice of one of the Wirepullers is Gorō Naya, who is notable for voicing all of the incarnations of the Great Leader in Kamen Rider, hinting that the Great Leader may be one of the people behind Smart Brain.